Fundamental studies on the hydration, erosion and release properties of biodegradable poly(esters)

E. Schmitt; D. R. Flanagan; R. J. Linhardt

Fundamental studies on the hydration, erosion and release properties of biodegradable poly(esters)

E. Schmitt, D. R. Flanagan, R. J. Linhardt

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Synthetic biodegradable poly(esters), in particular the homopolymers and copolymers of lactic and glycolic acids have been used for a variety of medical applications including the controlled release of drugs and biologicals [1]. The mechanism by which drugs are released from these polymers is complex involving both the physico-chemical and morphological properties of the incorporated drug and the polymeric matrix. In view of the large number of publications dealing with the release of drugs from poly(lactide-co-glycolide) matrices surprisingly little is known about the fundamentals of degradation and release. Recent work from our laboratory [2,3] and from Li and Vert [4,5,6] have begun to address some of these important issues.

Original language	English
Title of host publication	Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
Publisher	Publ by ACS
Pages	95-96
Number of pages	2
ISBN (Print)	0841222169
State	Published - 1992
Externally published	Yes

Publication series

Name	Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
Volume	66
ISSN (Print)	0743-0515

Cite this

Schmitt, E., Flanagan, D. R., & Linhardt, R. J. (1992). Fundamental studies on the hydration, erosion and release properties of biodegradable poly(esters). In Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering (pp. 95-96). (Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering; Vol. 66). Publ by ACS.

Schmitt, E. ; Flanagan, D. R. ; Linhardt, R. J. / Fundamental studies on the hydration, erosion and release properties of biodegradable poly(esters). Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. Publ by ACS, 1992. pp. 95-96 (Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering).

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abstract = "Synthetic biodegradable poly(esters), in particular the homopolymers and copolymers of lactic and glycolic acids have been used for a variety of medical applications including the controlled release of drugs and biologicals [1]. The mechanism by which drugs are released from these polymers is complex involving both the physico-chemical and morphological properties of the incorporated drug and the polymeric matrix. In view of the large number of publications dealing with the release of drugs from poly(lactide-co-glycolide) matrices surprisingly little is known about the fundamentals of degradation and release. Recent work from our laboratory [2,3] and from Li and Vert [4,5,6] have begun to address some of these important issues.",

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Schmitt, E, Flanagan, DR & Linhardt, RJ 1992, Fundamental studies on the hydration, erosion and release properties of biodegradable poly(esters). in Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering, vol. 66, Publ by ACS, pp. 95-96.

Fundamental studies on the hydration, erosion and release properties of biodegradable poly(esters). / Schmitt, E.; Flanagan, D. R.; Linhardt, R. J.
Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. Publ by ACS, 1992. p. 95-96 (Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering; Vol. 66).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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AU - Flanagan, D. R.

AU - Linhardt, R. J.

PY - 1992

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N2 - Synthetic biodegradable poly(esters), in particular the homopolymers and copolymers of lactic and glycolic acids have been used for a variety of medical applications including the controlled release of drugs and biologicals [1]. The mechanism by which drugs are released from these polymers is complex involving both the physico-chemical and morphological properties of the incorporated drug and the polymeric matrix. In view of the large number of publications dealing with the release of drugs from poly(lactide-co-glycolide) matrices surprisingly little is known about the fundamentals of degradation and release. Recent work from our laboratory [2,3] and from Li and Vert [4,5,6] have begun to address some of these important issues.

AB - Synthetic biodegradable poly(esters), in particular the homopolymers and copolymers of lactic and glycolic acids have been used for a variety of medical applications including the controlled release of drugs and biologicals [1]. The mechanism by which drugs are released from these polymers is complex involving both the physico-chemical and morphological properties of the incorporated drug and the polymeric matrix. In view of the large number of publications dealing with the release of drugs from poly(lactide-co-glycolide) matrices surprisingly little is known about the fundamentals of degradation and release. Recent work from our laboratory [2,3] and from Li and Vert [4,5,6] have begun to address some of these important issues.

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M3 - Conference contribution

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EP - 96

BT - Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering

PB - Publ by ACS

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Schmitt E, Flanagan DR, Linhardt RJ. Fundamental studies on the hydration, erosion and release properties of biodegradable poly(esters). In Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering. Publ by ACS. 1992. p. 95-96. (Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering).

Fundamental studies on the hydration, erosion and release properties of biodegradable poly(esters)

Abstract

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