Functional status at listing predicts waitlist and posttransplant mortality in pediatric liver transplant candidates

Emily R. Perito, John Bucuvalas, Jennifer C. Lai

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Functional impairment is associated with mortality in adult liver transplant candidates. This has not been studied in pediatric liver transplant candidates. United Network for Organ Sharing Standard Transplant Analysis and Research files were used to investigate functional status, waitlist mortality, and posttransplant outcomes in children younger than 18 years who were waitlisted in 2006-2016 for primary liver transplant. Functional status was categorized, by using the Lansky Play-Performance Scale (LPPS), as normal/good (80-100), moderately impaired (50-70), or severely impaired (10-40) by center assessment. Among 3250 children not listed as Status 1A, 62% had an LPPS score of 80-100, 25% had a score of 50-70, and 13% had a score of 10-40 at listing. Children with an LPPS score of 10-40 at listing were more likely to die while on the waitlist (standardized hazard ratio 1.85, 95% confidence interval 1.09-3.13, P =.02) in analyses adjusting for being on a ventilator, breathing support, or dialysis and other illness severity measures. For the 2565 children transplanted, an LPPS score of 10-40 at listing drastically increased mortality risk by 1 year posttransplant (hazard ratio 5.77, 95% confidence interval 3.05-10.91, P <.0005). LPPS scores of 10-40 and 50-70 both increased the risk of graft loss by 1 year. Functional status is an independent predictor of waitlist and posttransplant mortality in pediatric liver transplant candidates. Validated tools for the assessment of functional status in these children would improve our ability to predict mortality risk—and to appropriately prioritize them for transplant.

Original languageEnglish
Pages (from-to)1388-1396
Number of pages9
JournalAmerican Journal of Transplantation
Volume19
Issue number5
DOIs
StatePublished - May 2019

Keywords

  • United Network for Organ Sharing (UNOS)
  • clinical research/practice
  • health services and outcomes research
  • liver allograft function/dysfunction
  • liver transplantation/hepatology
  • organ allocation
  • pediatrics
  • waitlist management

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