Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva

Marie Saitou; Eliza A. Gaylord; Erica Xu; Alison J. May; Lubov Neznanova; Sara Nathan; Anissa Grawe; Jolie Chang; William Ryan; Stefan Ruhl; Sarah M. Knox; Omer Gokcumen

doi:10.1016/j.celrep.2020.108402

Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva

Marie Saitou, Eliza A. Gaylord, Erica Xu, Alison J. May, Lubov Neznanova, Sara Nathan, Anissa Grawe, Jolie Chang, William Ryan, Stefan Ruhl, Sarah M. Knox, Omer Gokcumen

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

Saitou et al. present a detailed analysis of transcriptome variation among human fetal and adult salivary glands. Their analysis reveals specific developmental and regulatory processes, as well as cell-line heterogeneity, that shape the gland-specific functional variation.

Original language	English
Article number	108402
Journal	Cell Reports
Volume	33
Issue number	7
DOIs	https://doi.org/10.1016/j.celrep.2020.108402
State	Published - 17 Nov 2020
Externally published	Yes

Keywords

cell-line heterogeneity
developmental regulation
gene regulation
glycosylation
lincRNAs
regulatory architecture
salivary biomarkers
salivary mucins
salivary proteins
transcriptome

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10.1016/j.celrep.2020.108402

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title = "Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva",

abstract = "Saitou et al. present a detailed analysis of transcriptome variation among human fetal and adult salivary glands. Their analysis reveals specific developmental and regulatory processes, as well as cell-line heterogeneity, that shape the gland-specific functional variation.",

keywords = "cell-line heterogeneity, developmental regulation, gene regulation, glycosylation, lincRNAs, regulatory architecture, salivary biomarkers, salivary mucins, salivary proteins, transcriptome",

author = "Marie Saitou and Gaylord, {Eliza A.} and Erica Xu and May, {Alison J.} and Lubov Neznanova and Sara Nathan and Anissa Grawe and Jolie Chang and William Ryan and Stefan Ruhl and Knox, {Sarah M.} and Omer Gokcumen",

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doi = "10.1016/j.celrep.2020.108402",

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AU - Saitou, Marie

AU - Gaylord, Eliza A.

AU - Xu, Erica

AU - May, Alison J.

AU - Neznanova, Lubov

AU - Nathan, Sara

AU - Grawe, Anissa

AU - Chang, Jolie

AU - Ryan, William

AU - Ruhl, Stefan

AU - Knox, Sarah M.

AU - Gokcumen, Omer

PY - 2020/11/17

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KW - cell-line heterogeneity

KW - developmental regulation

KW - gene regulation

KW - glycosylation

KW - lincRNAs

KW - regulatory architecture

KW - salivary biomarkers

KW - salivary mucins

KW - salivary proteins

KW - transcriptome

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DO - 10.1016/j.celrep.2020.108402

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JO - Cell Reports

JF - Cell Reports

IS - 7

M1 - 108402

ER -

Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva

Abstract

Keywords

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