Abstract
Recent evidence identified multiple Henipavirus species in Africa distinct from those in Southeast Asia and Australia. The reported fusion glycoprotein (F) sequence of the African Gh-M74a strain (GhV-F) is likely incorrect: a single base pair deletion near the N terminus results in multiple aberrancies. Rectifying this by adding single nucleotide insertions results in a GhV-F that now possesses a signal peptide, is efficiently cell surface expressed, exhibits syncytium formation when coexpressed with GhV-G protein, and mediates pseudotyped viral particle entry.
Original language | English |
---|---|
Pages (from-to) | 5171-5176 |
Number of pages | 6 |
Journal | Journal of Virology |
Volume | 88 |
Issue number | 9 |
DOIs | |
State | Published - May 2014 |