Functional rectification of the newly described African henipavirus fusion glycoprotein (Gh-M74a)

Olivier Pernet, Shannon Beaty, Benhur Lee

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Recent evidence identified multiple Henipavirus species in Africa distinct from those in Southeast Asia and Australia. The reported fusion glycoprotein (F) sequence of the African Gh-M74a strain (GhV-F) is likely incorrect: a single base pair deletion near the N terminus results in multiple aberrancies. Rectifying this by adding single nucleotide insertions results in a GhV-F that now possesses a signal peptide, is efficiently cell surface expressed, exhibits syncytium formation when coexpressed with GhV-G protein, and mediates pseudotyped viral particle entry.

Original languageEnglish
Pages (from-to)5171-5176
Number of pages6
JournalJournal of Virology
Volume88
Issue number9
DOIs
StatePublished - May 2014

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