Functional Neuroimaging Provides Evidence of Anomalous Cerebral Laterality in Adults with Klinefelter's Syndrome

Emmanuel Itti, Irene T. Gaw Gonzalo, Kyle B. Boone, Daniel H. Geschwind, Nancy Berman, Anna Pawlikowska-Haddal, Laurent Itti, Fred S. Mishkin, Ronald S. Swerdloff

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

This study aimed to characterize cerebral perfusion in men with Klinefelter's syndrome, known to present specific deficits in language, using 99mTc-hexamethylpropylene-amine-oxime (HMPAO) scintigraphy and Talairach normalization. While a perfusion asymmetry toward the left hemisphere was found in controls, perfusion was mostly symmetrical in Klinefelter patients in the upper temporal and lower parietal areas. Scores on verbal tests were inversely correlated with perfusion changes, providing neurobiological substrate of anomalous cerebral laterality.

Original languageEnglish
Pages (from-to)669-673
Number of pages5
JournalAnnals of Neurology
Volume54
Issue number5
DOIs
StatePublished - Nov 2003
Externally publishedYes

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