Functional grouping of osteoclast genes revealed through microarray analysis

Guozhe Yang; Mone Zaidi; Weijia Zhang; Ling Ling Zhu; Jianhua Li; Jameel Iqbal; Alex Varbanov; Gary Gross; Roger Phipps; Bruce R. Troen; Li Sun

doi:10.1016/j.bbrc.2007.11.106

Functional grouping of osteoclast genes revealed through microarray analysis

Guozhe Yang, Mone Zaidi, Weijia Zhang, Ling Ling Zhu, Jianhua Li, Jameel Iqbal, Alex Varbanov, Gary Gross, Roger Phipps, Bruce R. Troen, Li Sun

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21 Scopus citations

Abstract

We describe for the first time functional clusters of genes that are modulated during the differentiation of osteoclasts. Pathway analysis was applied to gene array data generated from affymetrix chips hybridized to RNA isolated from RAW264.7 cells exposed to RANK-ligand (RANK-L) for 5 days. This analysis revealed major functional gene clusters that were either up- or down-regulated during osteoclastogenesis. Some of the genes within the clusters have known functions, while others do not. We discuss herein the relevance of these functional gene clusters and their modulation to biological processes underlying the formation, function, and fate of osteoclasts.

Original language	English
Pages (from-to)	352-359
Number of pages	8
Journal	Biochemical and Biophysical Research Communications
Volume	366
Issue number	2
DOIs	https://doi.org/10.1016/j.bbrc.2007.11.106
State	Published - 8 Feb 2008

Keywords

Microarray
Osteoclast
Osteoclastogenesis
RANK-L

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10.1016/j.bbrc.2007.11.106

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title = "Functional grouping of osteoclast genes revealed through microarray analysis",

abstract = "We describe for the first time functional clusters of genes that are modulated during the differentiation of osteoclasts. Pathway analysis was applied to gene array data generated from affymetrix chips hybridized to RNA isolated from RAW264.7 cells exposed to RANK-ligand (RANK-L) for 5 days. This analysis revealed major functional gene clusters that were either up- or down-regulated during osteoclastogenesis. Some of the genes within the clusters have known functions, while others do not. We discuss herein the relevance of these functional gene clusters and their modulation to biological processes underlying the formation, function, and fate of osteoclasts.",

keywords = "Microarray, Osteoclast, Osteoclastogenesis, RANK-L",

author = "Guozhe Yang and Mone Zaidi and Weijia Zhang and Zhu, {Ling Ling} and Jianhua Li and Jameel Iqbal and Alex Varbanov and Gary Gross and Roger Phipps and Troen, {Bruce R.} and Li Sun",

note = "Funding Information: This study was supported by the National Institutes of Health (AG14197, DK70526, AG23176, to M.Z.) and by the Alliance for Better Bone Health.",

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T1 - Functional grouping of osteoclast genes revealed through microarray analysis

AU - Yang, Guozhe

AU - Zaidi, Mone

AU - Zhang, Weijia

AU - Zhu, Ling Ling

AU - Li, Jianhua

AU - Iqbal, Jameel

AU - Varbanov, Alex

AU - Gross, Gary

AU - Phipps, Roger

AU - Troen, Bruce R.

AU - Sun, Li

N1 - Funding Information: This study was supported by the National Institutes of Health (AG14197, DK70526, AG23176, to M.Z.) and by the Alliance for Better Bone Health.

PY - 2008/2/8

Y1 - 2008/2/8

N2 - We describe for the first time functional clusters of genes that are modulated during the differentiation of osteoclasts. Pathway analysis was applied to gene array data generated from affymetrix chips hybridized to RNA isolated from RAW264.7 cells exposed to RANK-ligand (RANK-L) for 5 days. This analysis revealed major functional gene clusters that were either up- or down-regulated during osteoclastogenesis. Some of the genes within the clusters have known functions, while others do not. We discuss herein the relevance of these functional gene clusters and their modulation to biological processes underlying the formation, function, and fate of osteoclasts.

AB - We describe for the first time functional clusters of genes that are modulated during the differentiation of osteoclasts. Pathway analysis was applied to gene array data generated from affymetrix chips hybridized to RNA isolated from RAW264.7 cells exposed to RANK-ligand (RANK-L) for 5 days. This analysis revealed major functional gene clusters that were either up- or down-regulated during osteoclastogenesis. Some of the genes within the clusters have known functions, while others do not. We discuss herein the relevance of these functional gene clusters and their modulation to biological processes underlying the formation, function, and fate of osteoclasts.

KW - Microarray

KW - Osteoclast

KW - Osteoclastogenesis

KW - RANK-L

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SP - 352

EP - 359

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

IS - 2

ER -

Functional grouping of osteoclast genes revealed through microarray analysis

Abstract

Keywords

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