Functional autoantibodies, a new paradigm in autoimmunity?

Norbert Gleicher, David Barad, Andrea Weghofer

Research output: Contribution to journalReview articlepeer-review

59 Scopus citations


The recent detection of stimulatory autoantibodies as a characteristic feature of systemic sclerosis (scleroderma), established the presence of such autoantibodies as a characteristic pathophysiologic finding in a second classical autoimmune disease after autoimmune thyroid disease. This observation raises the possibility of a new paradigm in abnormal autoimmune function, the presence of stimulatory (and suppressive), functional autoantibodies as characteristic features of abnormal autoimmune function. The assumption of such a paradigm opens interesting new research avenues within rheumatology and in other medical specialty areas. Within reproductive medicine, and akin to the concept of hypo- and hyperthyroidism, the possible juxtaposition of polycystic ovarian syndrome (PCOS) and premature ovarian aging (POA), as opposite abnormalities of adrenal function, under control of autoimmune adrenal antibodies, deserves further investigation.

Original languageEnglish
Pages (from-to)42-45
Number of pages4
JournalAutoimmunity Reviews
Issue number1
StatePublished - Nov 2007
Externally publishedYes


  • Autoantibodies
  • Autoimmune diseases
  • Autoimmunity
  • Polycystic ovarian syndrome (PCOS)
  • Premature ovarian aging (POA)
  • Scleroderma/systemic sclerosis
  • Thyroid disease


Dive into the research topics of 'Functional autoantibodies, a new paradigm in autoimmunity?'. Together they form a unique fingerprint.

Cite this