Functional and structural changes in liver mitochondria of rats due to CCl4 intoxication-II. Respiratory chain and ion transport

V. V. Lyachovich; V. M. Mishin; A. V. Dolgov; G. S. Jakobson; A. V. Panov; I. B. Tsyrlov

doi:10.1016/0006-2952(71)90272-3

Functional and structural changes in liver mitochondria of rats due to CCl₄ intoxication-II. Respiratory chain and ion transport

V. V. Lyachovich, V. M. Mishin, A. V. Dolgov, G. S. Jakobson, A. V. Panov, I. B. Tsyrlov

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The localization of electron-transport chain damage of NAD-Iinked substrates in liver mitochondria of rats intoxicated with CCl₄ has been studied in this work. It is shown that in experimental toxic hepatic lesion slow NADH₂ generation occurs, which is the cause of a depressed rate of oxidation of α-ketoglutarate, glutamate and pyruvate. In addition, important structural changes in mitochondrial membranes have been observed and may be considered to be the cause of disturbance of ion transport. The possible mechanisms of the appearance of revealed alterations are also discussed. It is presumed that primary impairment of the mitochondrial phospholipids is manifested in animals intoxicated by CCl₄.

Original language	English
Pages (from-to)	1443-1451
Number of pages	9
Journal	Biochemical Pharmacology
Volume	20
Issue number	7
DOIs	https://doi.org/10.1016/0006-2952(71)90272-3
State	Published - Jul 1971
Externally published	Yes

Access to Document

10.1016/0006-2952(71)90272-3

Cite this

@article{ae580af5500f46aabd2b2051bfdba257,

title = "Functional and structural changes in liver mitochondria of rats due to CCl4 intoxication-II. Respiratory chain and ion transport",

abstract = "The localization of electron-transport chain damage of NAD-Iinked substrates in liver mitochondria of rats intoxicated with CCl4 has been studied in this work. It is shown that in experimental toxic hepatic lesion slow NADH2 generation occurs, which is the cause of a depressed rate of oxidation of α-ketoglutarate, glutamate and pyruvate. In addition, important structural changes in mitochondrial membranes have been observed and may be considered to be the cause of disturbance of ion transport. The possible mechanisms of the appearance of revealed alterations are also discussed. It is presumed that primary impairment of the mitochondrial phospholipids is manifested in animals intoxicated by CCl4.",

author = "Lyachovich, {V. V.} and Mishin, {V. M.} and Dolgov, {A. V.} and Jakobson, {G. S.} and Panov, {A. V.} and Tsyrlov, {I. B.}",

year = "1971",

month = jul,

doi = "10.1016/0006-2952(71)90272-3",

language = "English",

volume = "20",

pages = "1443--1451",

journal = "Biochemical Pharmacology",

issn = "0006-2952",

publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - Functional and structural changes in liver mitochondria of rats due to CCl4 intoxication-II. Respiratory chain and ion transport

AU - Lyachovich, V. V.

AU - Mishin, V. M.

AU - Dolgov, A. V.

AU - Jakobson, G. S.

AU - Panov, A. V.

AU - Tsyrlov, I. B.

PY - 1971/7

Y1 - 1971/7

N2 - The localization of electron-transport chain damage of NAD-Iinked substrates in liver mitochondria of rats intoxicated with CCl4 has been studied in this work. It is shown that in experimental toxic hepatic lesion slow NADH2 generation occurs, which is the cause of a depressed rate of oxidation of α-ketoglutarate, glutamate and pyruvate. In addition, important structural changes in mitochondrial membranes have been observed and may be considered to be the cause of disturbance of ion transport. The possible mechanisms of the appearance of revealed alterations are also discussed. It is presumed that primary impairment of the mitochondrial phospholipids is manifested in animals intoxicated by CCl4.

AB - The localization of electron-transport chain damage of NAD-Iinked substrates in liver mitochondria of rats intoxicated with CCl4 has been studied in this work. It is shown that in experimental toxic hepatic lesion slow NADH2 generation occurs, which is the cause of a depressed rate of oxidation of α-ketoglutarate, glutamate and pyruvate. In addition, important structural changes in mitochondrial membranes have been observed and may be considered to be the cause of disturbance of ion transport. The possible mechanisms of the appearance of revealed alterations are also discussed. It is presumed that primary impairment of the mitochondrial phospholipids is manifested in animals intoxicated by CCl4.

UR - http://www.scopus.com/inward/record.url?scp=0015083336&partnerID=8YFLogxK

U2 - 10.1016/0006-2952(71)90272-3

DO - 10.1016/0006-2952(71)90272-3

M3 - Article

C2 - 4355302

AN - SCOPUS:0015083336

SN - 0006-2952

VL - 20

SP - 1443

EP - 1451

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 7

ER -

Functional and structural changes in liver mitochondria of rats due to CCl4 intoxication-II. Respiratory chain and ion transport

Abstract

Access to Document

Fingerprint

Cite this

Functional and structural changes in liver mitochondria of rats due to CCl₄ intoxication-II. Respiratory chain and ion transport