Functional and structural changes in liver mitochondria of rats due to CCl4 intoxication-I. Studies on state of electron-transport chain

V. V. Lyachovich, V. M. Mishin, A. V. Dolgov, I. B. Tsyrlov

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Functional changes in the electron-transport chain in the liver mitochondria of rats, induced by carbon tetrachloride treatment, have been studied in this work. Experimental evidence led us to the conclusion that along with uncoupling of oxidative phosphorylation, impairment of the respiratory chain is observed. The decrease in the rate of succinate oxidation is thought to be due to a deficit in cytochrome c. The marked respiratory inhibition observed during NAD-linked substrate oxidation is considered to be caused by impairment of either the first complex or the substrate dehydrogenases.

Original languageEnglish
Pages (from-to)1437-1441
Number of pages5
JournalBiochemical Pharmacology
Volume20
Issue number7
DOIs
StatePublished - Jul 1971
Externally publishedYes

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