Functional and antigenic properties of cultured T cells in the cell mediated lympholysis (CML) assay

Karen S. Zier

doi:10.1016/0198-8859(82)90014-3

Functional and antigenic properties of cultured T cells in the cell mediated lympholysis (CML) assay

Karen S. Zier

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Cultured T cells (CTC) were expanded in Interleukin-2 (IL-2) and used as reagents in cell mediated lympholysis (CML). CTC were able to induce the generation of primary cytotoxic effector cells and to function as ⁵¹Cr labeled target cells and cold target inhibitors. Since large numbers of CTC can be produced from as few as 1-2 × 10⁶ lymphocytes within a short period of time, these reagents with enable CML studies to be performed in a broader range of situations including those which were heretofore impossible.

Original language	English
Pages (from-to)	147-156
Number of pages	10
Journal	Human Immunology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1016/0198-8859(82)90014-3
State	Published - Apr 1982
Externally published	Yes

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title = "Functional and antigenic properties of cultured T cells in the cell mediated lympholysis (CML) assay",

abstract = "Cultured T cells (CTC) were expanded in Interleukin-2 (IL-2) and used as reagents in cell mediated lympholysis (CML). CTC were able to induce the generation of primary cytotoxic effector cells and to function as 51Cr labeled target cells and cold target inhibitors. Since large numbers of CTC can be produced from as few as 1-2 × 106 lymphocytes within a short period of time, these reagents with enable CML studies to be performed in a broader range of situations including those which were heretofore impossible.",

author = "Zier, \{Karen S.\}",

year = "1982",

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journal = "Human Immunology",

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T1 - Functional and antigenic properties of cultured T cells in the cell mediated lympholysis (CML) assay

AU - Zier, Karen S.

PY - 1982/4

Y1 - 1982/4

N2 - Cultured T cells (CTC) were expanded in Interleukin-2 (IL-2) and used as reagents in cell mediated lympholysis (CML). CTC were able to induce the generation of primary cytotoxic effector cells and to function as 51Cr labeled target cells and cold target inhibitors. Since large numbers of CTC can be produced from as few as 1-2 × 106 lymphocytes within a short period of time, these reagents with enable CML studies to be performed in a broader range of situations including those which were heretofore impossible.

AB - Cultured T cells (CTC) were expanded in Interleukin-2 (IL-2) and used as reagents in cell mediated lympholysis (CML). CTC were able to induce the generation of primary cytotoxic effector cells and to function as 51Cr labeled target cells and cold target inhibitors. Since large numbers of CTC can be produced from as few as 1-2 × 106 lymphocytes within a short period of time, these reagents with enable CML studies to be performed in a broader range of situations including those which were heretofore impossible.

UR - https://www.scopus.com/pages/publications/0020284224

U2 - 10.1016/0198-8859(82)90014-3

DO - 10.1016/0198-8859(82)90014-3

M3 - Article

C2 - 6978875

AN - SCOPUS:0020284224

SN - 0198-8859

VL - 4

SP - 147

EP - 156

JO - Human Immunology

JF - Human Immunology

IS - 2

ER -

Functional and antigenic properties of cultured T cells in the cell mediated lympholysis (CML) assay

Abstract

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