Functional activity of protein C in newborn infants: A report of a study and a review of the literature

Pratibha Ankola; Michael Nardi; Margaret Karpatkin

doi:10.1097/00043426-199205000-00008

Functional activity of protein C in newborn infants: A report of a study and a review of the literature

Pratibha Ankola, Michael Nardi, Margaret Karpatkin

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9 Scopus citations

Abstract

Protein C is lower in newborn infants than in adults. There are conflicting reports regarding functional activity and the presence of des-γ carboxylated species in the newborn. We have compared protein C activity and antigenic level in newborn infants and found the activity: antigen ratio to be lower than in adults (0.69 versus 1.0). We discuss this finding in relation to the previously published reports.

Original language	English
Pages (from-to)	140-143
Number of pages	4
Journal	Journal of Pediatric Hematology/Oncology
Volume	14
Issue number	2
DOIs	https://doi.org/10.1097/00043426-199205000-00008
State	Published - May 1992
Externally published	Yes

Keywords

Blood
Des-γ carboxylated protein
Newborns
Protein C
Thrombosis
Vitamin K

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10.1097/00043426-199205000-00008

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abstract = "Protein C is lower in newborn infants than in adults. There are conflicting reports regarding functional activity and the presence of des-γ carboxylated species in the newborn. We have compared protein C activity and antigenic level in newborn infants and found the activity: antigen ratio to be lower than in adults (0.69 versus 1.0). We discuss this finding in relation to the previously published reports.",

keywords = "Blood, Des-γ carboxylated protein, Newborns, Protein C, Thrombosis, Vitamin K",

author = "Pratibha Ankola and Michael Nardi and Margaret Karpatkin",

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AU - Karpatkin, Margaret

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AB - Protein C is lower in newborn infants than in adults. There are conflicting reports regarding functional activity and the presence of des-γ carboxylated species in the newborn. We have compared protein C activity and antigenic level in newborn infants and found the activity: antigen ratio to be lower than in adults (0.69 versus 1.0). We discuss this finding in relation to the previously published reports.

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KW - Des-γ carboxylated protein

KW - Newborns

KW - Protein C

KW - Thrombosis

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Functional activity of protein C in newborn infants: A report of a study and a review of the literature

Abstract

Keywords

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