Fulminant endocarditis and disseminated infection caused by carbapenem-resistant Acinetobacter baumannii in a renal-pancreas transplant recipient

G. Patel, F. Perez, A. M. Hujer, S. D. Rudin, J. J. Augustine, G. H. Jacobs, M. R. Jacobs, R. A. Bonomo

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Acinetobacter baumannii is an important cause of healthcare-associated infections, and is particularly problematic among patients who undergo organ transplantation. We describe a case of fulminant sepsis caused by carbapenem-resistant A. baumannii harboring the blaOXA-23 carbapenemase gene and belonging to international clone II. This isolate led to the death of a patient 6 days after simultaneous kidney-pancreas transplantation. Autopsy findings revealed acute mitral valve endocarditis, myocarditis, splenic and renal emboli, peritonitis, and pneumonia. This case highlights the severe nature of certain A. baumannii infections and the vulnerability of transplanted patients to the increasingly intractable "high-risk" clones of multidrug-resistant organisms.

Original languageEnglish
Pages (from-to)289-296
Number of pages8
JournalTransplant Infectious Disease
Volume17
Issue number2
DOIs
StatePublished - 1 Apr 2015

Keywords

  • Acinetobacter baumannii
  • Carbapenem resistance
  • Endocarditis
  • Simultaneous kidney-pancreas transplantation

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