Fucosylated chondroitin sulfate from Isostichopus badionotus alleviates metabolic syndromes and gut microbiota dysbiosis induced by high-fat and high-fructose diet

Shan Li, Junhui Li, Guizhu Mao, Tiantian Wu, Dingbo Lin, Yaqin Hu, Xingqian Ye, Ding Tian, Wengang Chai, Robert J. Linhardt, Shiguo Chen

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Fucosylated chondroitin sulfate from Isostichopus badionotus (fCS-Ib) is a kind of sulfated polysaccharides with well-repeated structure. In our former publications, fCS-Ib has been reported to be a functional food ingredient with hypoglycemic and antilipemic activities. However, there is no systematic study to investigate the effects of fCS-Ib on metabolic syndromes. In the present study, C57BL/6 mice fed on a high-fat and high sucrose diet (HFSD) for 6 weeks was used to cause metabolic syndromes. The final results showed that fCS-Ib alleviated obesity, hyperlipidemia, hyperglycemia, inflammation, liver steatosis, and adipocyte hypertrophy caused by HFSD. Meanwhile, fCS-Ib showed powerful effects on moderating gut microbiota dysbiosis in the HFSD-fed mice. Supplement of fCS-Ib could reduce ratio of Firmicutes to Bacteroidetes by decreasing abundance of Lachnospiraceae and Allobaculum while increasing abundance of Porphyromonadaceae, Barnesiella, and Bacteroides. Our results showed that fCS-Ib could be further developed as a potential pharmaceutical agent to prevent metabolic syndromes and gut microbiota dysbiosis.

Original languageEnglish
Pages (from-to)377-388
Number of pages12
JournalInternational Journal of Biological Macromolecules
Volume124
DOIs
StatePublished - 1 Mar 2019
Externally publishedYes

Keywords

  • Fucosylated chondroitin sulfate from sea cucumber
  • Gut microbiota
  • High-fat and high-sucrose diet
  • Metabolic syndromes

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