FSH Level and Changes in Bone Mass and Body Composition in Older Women and Men

Karin C. Wu, Susan K. Ewing, Xiaojuan Li, Sigurour Sigurosson, Vilmundur Guonason, Deborah M. Kado, Trisha F. Hue, Gina N. Woods, Annegreet G. Veldhuis-Vlug, Eric Vittinghoff, Mone Zaidi, Clifford J. Rosen, Thomas Lang, Tiffany Y. Kim, Ann V. Schwartz, Anne L. Schafer

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Context: FSH may have independent actions on bone remodeling and body fat regulation. Cross-sectionally, we have shown that serum FSH is associated with bone mineral density (BMD) and body fat in older postmenopausal women, but it remains unknown whether FSH predicts bone and fat changes. Objective: We examined whether baseline FSH level is associated with subsequent bone loss or body composition changes in older adults. Setting, Design, Participants: We studied 162 women and 158 men (mean age 82 ± 4 years) from the Age, Gene/Environment Susceptibility (AGES)-Bone Marrow Adiposity cohort, a substudy of the AGES-Reykjavik Study of community-dwelling older adults. Skeletal health and body composition were characterized at baseline and 3 years later. Main Outcomes: Annualized change in BMD and body composition by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT). Models were adjusted for serum estradiol and testosterone levels. Results: There was no evidence for an association between baseline FSH level and change in BMD or body composition by DXA or QCT. For femoral neck areal BMD, adjusted mean difference (95% CI) per SD increase in FSH was 1.3 (-0.7 to 3.3) mg/cm2/y in women, and -0.2 (-2.6 to 2.2) mg/cm2/y in men. For visceral fat, adjusted mean difference (95% CI) per SD increase in FSH was 1.80 (-0.03 to 3.62) cm2/y in women, and -0.33 (-3.73 to 3.06) cm2/y in men. Conclusions: Although cross-sectional studies and studies in perimenopausal women have demonstrated associations between FSH and BMD and body composition, in older adults, FSH level is not associated with bone mass or body composition changes.

Original languageEnglish
Pages (from-to)2876-2889
Number of pages14
JournalJournal of Clinical Endocrinology and Metabolism
Volume106
Issue number10
DOIs
StatePublished - 1 Oct 2021

Keywords

  • adiposity
  • aging
  • body composition
  • bone loss
  • follicle-stimulating hormone (FSH)

Fingerprint

Dive into the research topics of 'FSH Level and Changes in Bone Mass and Body Composition in Older Women and Men'. Together they form a unique fingerprint.

Cite this