FSH beyond fertility

Daria Lizneva, Alina Rahimova, Se Min Kim, Ihor Atabiekov, Seher Javaid, Bateel Alamoush, Charit Taneja, Ayesha Khan, Li Sun, Ricardo Azziz, Tony Yuen, Mone Zaidi

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations

Abstract

The traditional view of follicle-stimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data suggest that elevated serum FSH may play a significant role in the evolution of bone loss and obesity, as well as contributing to cardiovascular and cancer risk. This review summarizes recent data on FSH action beyond reproduction.

Original languageEnglish
Article number136
JournalFrontiers in Endocrinology
Volume10
Issue numberMAR
DOIs
StatePublished - 2019

Keywords

  • BMI
  • FSH
  • FSHR
  • cardiovascular risk
  • obesity
  • osteoporosis

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