FSH beyond fertility

Daria Lizneva; Alina Rahimova; Se Min Kim; Ihor Atabiekov; Seher Javaid; Bateel Alamoush; Charit Taneja; Ayesha Khan; Li Sun; Ricardo Azziz; Tony Yuen; Mone Zaidi

doi:10.3389/fendo.2019.00136

FSH beyond fertility

Daria Lizneva, Alina Rahimova, Se Min Kim, Ihor Atabiekov, Seher Javaid, Bateel Alamoush, Charit Taneja, Ayesha Khan, Li Sun, Ricardo Azziz, Tony Yuen, Mone Zaidi

Research output: Contribution to journal › Review article › peer-review

35 Scopus citations

Abstract

The traditional view of follicle-stimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data suggest that elevated serum FSH may play a significant role in the evolution of bone loss and obesity, as well as contributing to cardiovascular and cancer risk. This review summarizes recent data on FSH action beyond reproduction.

Original language	English
Article number	136
Journal	Frontiers in Endocrinology
Volume	10
Issue number	MAR
DOIs	https://doi.org/10.3389/fendo.2019.00136
State	Published - 2019

Keywords

BMI
FSH
FSHR
cardiovascular risk
obesity
osteoporosis

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title = "FSH beyond fertility",

abstract = "The traditional view of follicle-stimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data suggest that elevated serum FSH may play a significant role in the evolution of bone loss and obesity, as well as contributing to cardiovascular and cancer risk. This review summarizes recent data on FSH action beyond reproduction.",

keywords = "BMI, FSH, FSHR, cardiovascular risk, obesity, osteoporosis",

author = "Daria Lizneva and Alina Rahimova and Kim, {Se Min} and Ihor Atabiekov and Seher Javaid and Bateel Alamoush and Charit Taneja and Ayesha Khan and Li Sun and Ricardo Azziz and Tony Yuen and Mone Zaidi",

note = "Funding Information: Work at Icahn School of Medicine at Mount Sinai was supported by the National Institutes of Health (NIH) by R01 Grants DK113627 to (MZ and LS), AG40132 (to MZ), AR65932 (to MZ), AR67066 (to MZ). Publisher Copyright: {\textcopyright} 2019 Lizneva, Rahimova, Kim, Atabiekov, Javaid, Alamoush, Taneja, Khan, Sun, Azziz, Yuen and Zaidi.",

year = "2019",

doi = "10.3389/fendo.2019.00136",

language = "English",

volume = "10",

journal = "Frontiers in Endocrinology",

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T1 - FSH beyond fertility

AU - Lizneva, Daria

AU - Rahimova, Alina

AU - Kim, Se Min

AU - Atabiekov, Ihor

AU - Javaid, Seher

AU - Alamoush, Bateel

AU - Taneja, Charit

AU - Khan, Ayesha

AU - Sun, Li

AU - Azziz, Ricardo

AU - Yuen, Tony

AU - Zaidi, Mone

N1 - Funding Information: Work at Icahn School of Medicine at Mount Sinai was supported by the National Institutes of Health (NIH) by R01 Grants DK113627 to (MZ and LS), AG40132 (to MZ), AR65932 (to MZ), AR67066 (to MZ). Publisher Copyright: © 2019 Lizneva, Rahimova, Kim, Atabiekov, Javaid, Alamoush, Taneja, Khan, Sun, Azziz, Yuen and Zaidi.

PY - 2019

Y1 - 2019

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AB - The traditional view of follicle-stimulating hormone (FSH) as a reproductive hormone is changing. It has been shown that FSH receptors (FSHRs) are expressed in various extra-gonadal tissues and mediate the biological effects of FSH at those sites. Molecular, animal, epidemiologic, and clinical data suggest that elevated serum FSH may play a significant role in the evolution of bone loss and obesity, as well as contributing to cardiovascular and cancer risk. This review summarizes recent data on FSH action beyond reproduction.

KW - BMI

KW - FSH

KW - FSHR

KW - cardiovascular risk

KW - obesity

KW - osteoporosis

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VL - 10

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

IS - MAR

M1 - 136

ER -

FSH beyond fertility

Abstract

Keywords

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