@article{5f41e2d7dd1e4955a8db2a55cbedd29f,
title = "Fructus Ligustri Lucidi preserves bone quality through induction of canonical Wnt/β-catenin signaling pathway in ovariectomized rats",
abstract = "Fructus Ligustri Lucidi (FLL) has been preclinically and clinically used to treat musculoskeletal diseases. However, whether and how FLL affect the canonical Wnt/β-catenin signaling in the management of osteoporosis remains largely unknown. To this end, ovariectomized (OVX) rats and primary osteoblasts were administrated with FLL aqueous extract and medicated serum, respectively. Supplement of FLL to OVX rats maintains bone quality by attenuating the reduction in bone mineral density, strength and microstructure. The maintenance may be associated with upregulating the expression of insulin-like growth factor-1, osteoprotegerin, phospho (p)-low-density lipoprotein receptor-related protein 6, p-glycogen synthase kinase 3 beta (GSK3β), β-catenin, Runx2 and c-Myc, and downregulating the expressions of sclerostin (SOST), dickkopf-related protein 1 (DKK1), GSK3β and p-β-catenin in rat femurs and tibias. In addition, the medicated serum promotes osteoblastic bone formation through activation of Wnt/β-catenin signaling via inhibition of DKK1 and SOST overexpression. Salidroside may be one of the active ingredients in FLL that are beneficial for bone homeostasis. In summary, our results suggest that FLL may preserve bone quality through induction of canonical Wnt/β-catenin signaling via inhibition of DKK1 and SOST overexpression. And FLL may offer a new source of the DKK1 or SOST inhibitors in protection against osteoporosis.",
keywords = "Fructus Ligustri Lucidi, Wnt/β-catenin, bone quality, medicated serum, ovariectomized rats, primary osteoblasts",
author = "Haixia Liu and Yubo Guo and Ruyuan Zhu and Lili Wang and Beibei Chen and Yimiao Tian and Rui Li and Rufeng Ma and Qiangqiang Jia and Hao Zhang and Bingke Xia and Yu Li and Xinxiang Wang and Xiaofeng Zhu and Ronghua Zhang and Dieter Brӧmme and Sihua Gao and Dongwei Zhang and Xiaohua Pei",
note = "Funding Information: The authors thank Angela Tether at University of British Columbia for the thorough English editing of the manuscript. Dr. Dongwei Zhang received grants to conduct this study from the Beijing Municipal Natural Science Foundation (7172126), and the National Natural Science Foundation of China (NSFC81874373). Dr. Sihua Gao received a grant from the Program for QiHuang Scholar (Sihua Gao) in State Administration of Traditional Chinese Medicine. Dr. Yu Li received a grant from the Program for Innovative Research Team in University (Grant No. IRT_17R11). Dr. Dieter Brӧmme received a grant from the Canadian Institute of Health Research (CIHR‐MOP). Dr. Xiaofeng Zhu and Ronghua Zhang received the grants from National Key Research and Development Plan (2018YFC2002500) and National Natural Science Foundation of China (NSFC81673837). Funding Information: National Key Research and Development Plan, Grant/Award Number: 2018YFC2002500; Program for Innovative Research Team in University, Grant/Award Number: IRT_17R11; Beijing Municipal Natural Science Foundation, Grant/Award Number: 7172126; Canadian Institute of Health Research, Grant/Award Number: CIHR‐MOP; National Natural Science Foundation of China, Grant/Award Number: 81874373; 81673837; Program for QiHuang Scholar (Sihua Gao) in State Administration of Traditional Chinese Medicine Funding information Publisher Copyright: {\textcopyright} 2020 John Wiley & Sons Ltd",
year = "2021",
month = jan,
doi = "10.1002/ptr.6817",
language = "English",
volume = "35",
pages = "424--441",
journal = "Phytotherapy Research",
issn = "0951-418X",
publisher = "John Wiley and Sons Ltd",
number = "1",
}