106 Scopus citations


Planar cell polarity (PCP) provides positional information to direct tissue patterning and morphogenesis. While much of the molecular detail of the pathway has been delineated in Drosophila, ensuing studies have shown considerable conservation of both the components and mechanisms of signaling in vertebrates. A recognized feature of PCP is the asymmetric localization of components that translates a global directional cue into a polarized downstream output. Here we discuss recent advances in the PCP field, from the organization of these asymmetric complexes to their upstream directional regulation by Wnt ligands. We also discuss the impact of Wnt/PCP signaling in disease and more specifically an emerging role in cancer progression.

Original languageEnglish
Pages (from-to)110-116
Number of pages7
JournalCurrent Opinion in Cell Biology
StatePublished - Apr 2018


Dive into the research topics of 'From instruction to output: Wnt/PCP signaling in development and cancer'. Together they form a unique fingerprint.

Cite this