TY - JOUR
T1 - From instruction to output
T2 - Wnt/PCP signaling in development and cancer
AU - Humphries, Ashley Ceinwen
AU - Mlodzik, Marek
N1 - Funding Information:
The authors wish to thank Christopher M. Smith, MA, CMI and the Academic Medical Illustration Department at the Icahn School of Medicine at Mount Sinai for assistance with figure preparation. Related research in the laboratory is supported by National Institutes of Health grants from NIGMS and NEI (to M.M.) and EMBO (post-doctoral fellowship to A.C.H.)
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2018/4
Y1 - 2018/4
N2 - Planar cell polarity (PCP) provides positional information to direct tissue patterning and morphogenesis. While much of the molecular detail of the pathway has been delineated in Drosophila, ensuing studies have shown considerable conservation of both the components and mechanisms of signaling in vertebrates. A recognized feature of PCP is the asymmetric localization of components that translates a global directional cue into a polarized downstream output. Here we discuss recent advances in the PCP field, from the organization of these asymmetric complexes to their upstream directional regulation by Wnt ligands. We also discuss the impact of Wnt/PCP signaling in disease and more specifically an emerging role in cancer progression.
AB - Planar cell polarity (PCP) provides positional information to direct tissue patterning and morphogenesis. While much of the molecular detail of the pathway has been delineated in Drosophila, ensuing studies have shown considerable conservation of both the components and mechanisms of signaling in vertebrates. A recognized feature of PCP is the asymmetric localization of components that translates a global directional cue into a polarized downstream output. Here we discuss recent advances in the PCP field, from the organization of these asymmetric complexes to their upstream directional regulation by Wnt ligands. We also discuss the impact of Wnt/PCP signaling in disease and more specifically an emerging role in cancer progression.
UR - http://www.scopus.com/inward/record.url?scp=85039741135&partnerID=8YFLogxK
U2 - 10.1016/j.ceb.2017.12.005
DO - 10.1016/j.ceb.2017.12.005
M3 - Review article
C2 - 29289896
AN - SCOPUS:85039741135
SN - 0955-0674
VL - 51
SP - 110
EP - 116
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
ER -