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From GWAS to GEMMs: Sestrin1 and cholesterol biosynthesis
Emily J. Gallagher
Cancer Mechanisms
Graduate School of Biomedical Sciences
Icahn School of Medicine at Mount Sinai
Medicine - Endocrinology, Diabetes and Bone Disease
The Tisch Cancer Institute
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Medicine & Life Sciences
Genome-Wide Association Study
100%
Cholesterol
70%
Lipids
62%
Liver
43%
Genes
34%
Human Genome
33%
glutaryl-coenzyme A
32%
Dyslipidemias
20%
Datasets
16%
Anticholesteremic Agents
15%
Genome
14%
Acetyl-CoA Carboxylase
14%
very low density lipoprotein triglyceride
14%
Western Diet
14%
VLDL Cholesterol
13%
AMP-Activated Protein Kinases
12%
Veterans
11%
High Fat Diet
10%
Proteomics
9%
Oxidoreductases
9%
Coronary Artery Disease
8%
Homeostasis
7%
Phosphorylation
7%
Gene Expression
6%
Animals
5%
Therapeutics
5%