'From blood to blood': De-differentiation of hematopoietic progenitors to stem cells

Carlos Filipe Pereira; Ihor R. Lemischka; Kateri Moore

doi:10.15252/embj.201488980

'From blood to blood': De-differentiation of hematopoietic progenitors to stem cells

Carlos Filipe Pereira, Ihor R. Lemischka, Kateri Moore

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors (TFs) into cells with hematopoietic potential. A study published in Cell now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell et al, 2014). The authors report that a combination of eight TFs reprogram murine committed blood progenitors into long-term engrafting and serially transplantable hematopoietic stem cells with a molecular signature similar to their endogenous counterparts.

Original language	English
Pages (from-to)	1511-1513
Number of pages	3
Journal	EMBO Journal
Volume	33
Issue number	14
DOIs	https://doi.org/10.15252/embj.201488980
State	Published - 17 Jul 2014

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title = "'From blood to blood': De-differentiation of hematopoietic progenitors to stem cells",

abstract = "Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors (TFs) into cells with hematopoietic potential. A study published in Cell now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell et al, 2014). The authors report that a combination of eight TFs reprogram murine committed blood progenitors into long-term engrafting and serially transplantable hematopoietic stem cells with a molecular signature similar to their endogenous counterparts.",

author = "Pereira, {Carlos Filipe} and Lemischka, {Ihor R.} and Kateri Moore",

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AU - Pereira, Carlos Filipe

AU - Lemischka, Ihor R.

AU - Moore, Kateri

PY - 2014/7/17

Y1 - 2014/7/17

N2 - Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors (TFs) into cells with hematopoietic potential. A study published in Cell now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell et al, 2014). The authors report that a combination of eight TFs reprogram murine committed blood progenitors into long-term engrafting and serially transplantable hematopoietic stem cells with a molecular signature similar to their endogenous counterparts.

AB - Recent studies have reported that fibroblasts or differentiated pluripotent cells can be reprogrammed with transcription factors (TFs) into cells with hematopoietic potential. A study published in Cell now suggests that committed blood precursors may provide a source for blood stem cell transplantation after reprogramming (Riddell et al, 2014). The authors report that a combination of eight TFs reprogram murine committed blood progenitors into long-term engrafting and serially transplantable hematopoietic stem cells with a molecular signature similar to their endogenous counterparts.

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JF - EMBO Journal

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'From blood to blood': De-differentiation of hematopoietic progenitors to stem cells

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