TY - JOUR
T1 - From A to Z
T2 - Apical structures and zona pellucida-domain proteins
AU - Plaza, Serge
AU - Chanut-Delalande, Hélène
AU - Fernandes, Isabelle
AU - Wassarman, Paul M.
AU - Payre, François
N1 - Funding Information:
This work was supported by grants from the Association pour la Recherche contre le Cancer (no. 3832, no. 1111 and a fellowship to I.F.), Fondation pour la Recherche Médicale (équipe 2005), and ANR Blanc Netoshape. The Wassarman laboratory was supported by the National Institute of Health (NICHD), most recently by grant HD-35105. We thank P. Ferrer for critical reading of the manuscript. The authors have declared no conflict of interest.
PY - 2010/9
Y1 - 2010/9
N2 - The terminal differentiation of epithelial cells involves changes in the apical compartment, including remodeling of the cytoskeleton and junctions to modify its three-dimensional organization. It also often triggers the building of specialized extracellular matrices, the function of which remains poorly understood. Hundreds of extracellular matrix proteins expressed in a variety of epithelia possess a conserved region called the zona pellucida-domain (ZP domain). There is evidence to suggest that ZP-domains mediate the polymerization of proteins into fibrils or matrices and that mutation of ZP-domains can result in severe pathologies, such as infertility, deafness, and cancer. Recent work in worms and flies demonstrates that ZP-domain proteins play a crucial role in organizing and shaping highly specialized apical structures in epithelial cells.
AB - The terminal differentiation of epithelial cells involves changes in the apical compartment, including remodeling of the cytoskeleton and junctions to modify its three-dimensional organization. It also often triggers the building of specialized extracellular matrices, the function of which remains poorly understood. Hundreds of extracellular matrix proteins expressed in a variety of epithelia possess a conserved region called the zona pellucida-domain (ZP domain). There is evidence to suggest that ZP-domains mediate the polymerization of proteins into fibrils or matrices and that mutation of ZP-domains can result in severe pathologies, such as infertility, deafness, and cancer. Recent work in worms and flies demonstrates that ZP-domain proteins play a crucial role in organizing and shaping highly specialized apical structures in epithelial cells.
UR - http://www.scopus.com/inward/record.url?scp=77956186616&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2010.06.002
DO - 10.1016/j.tcb.2010.06.002
M3 - Review article
C2 - 20598543
AN - SCOPUS:77956186616
SN - 0962-8924
VL - 20
SP - 524
EP - 532
JO - Trends in Cell Biology
JF - Trends in Cell Biology
IS - 9
ER -