TY - JOUR
T1 - Frizzled/PCP signalling
T2 - A conserved mechanism regulating cell polarity and directed motility
AU - Seifert, Jessica R.K.
AU - Mlodzik, Marek
N1 - Funding Information:
We are grateful to D. del Alamo, W. Gault and S. Sokol for comments on the manuscript, to A. Jenny for help with FIG. 2, and to all members of the Mlodzik’s laboratory for discussions. We thank B. Ciruna, M.W. Kelley and J. Nathans for some of the panels shown in FIG. 1 and discussions. We apologize to investigators whose work is only cited indirectly through earlier reviews. Our work is supported by grants from the National Institute of General Medical Sciences and the National Eye Institute of the National Institutes of Health.
PY - 2007/2
Y1 - 2007/2
N2 - Signalling through Frizzled (Fz)/planar cell polarity (PCP) is a conserved mechanism that polarizes cells along specific axes in a tissue. Genetic screens in Drosophila melanogaster pioneered the discovery of core PCP factors, which regulate the orientation of hairs on wings and facets in eyes. Recent genetic evidence shows that the Fz/PCP pathway is conserved in vertebrates and is crucial for disparate processes as gastrulation and sensory cell orientation. Fz/PCP signalling depends on complex interactions between core components, leading to their asymmetric distribution and ultimately polarized activity in a cell. Whereas several mechanistic aspects of PCP have been uncovered, the global coordination of this polarization remains debated.
AB - Signalling through Frizzled (Fz)/planar cell polarity (PCP) is a conserved mechanism that polarizes cells along specific axes in a tissue. Genetic screens in Drosophila melanogaster pioneered the discovery of core PCP factors, which regulate the orientation of hairs on wings and facets in eyes. Recent genetic evidence shows that the Fz/PCP pathway is conserved in vertebrates and is crucial for disparate processes as gastrulation and sensory cell orientation. Fz/PCP signalling depends on complex interactions between core components, leading to their asymmetric distribution and ultimately polarized activity in a cell. Whereas several mechanistic aspects of PCP have been uncovered, the global coordination of this polarization remains debated.
UR - https://www.scopus.com/pages/publications/33846396811
U2 - 10.1038/nrg2042
DO - 10.1038/nrg2042
M3 - Review article
C2 - 17230199
AN - SCOPUS:33846396811
SN - 1471-0056
VL - 8
SP - 126
EP - 138
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 2
ER -