Frizzled/PCP signalling: A conserved mechanism regulating cell polarity and directed motility

Jessica R.K. Seifert, Marek Mlodzik

Research output: Contribution to journalReview articlepeer-review

382 Scopus citations

Abstract

Signalling through Frizzled (Fz)/planar cell polarity (PCP) is a conserved mechanism that polarizes cells along specific axes in a tissue. Genetic screens in Drosophila melanogaster pioneered the discovery of core PCP factors, which regulate the orientation of hairs on wings and facets in eyes. Recent genetic evidence shows that the Fz/PCP pathway is conserved in vertebrates and is crucial for disparate processes as gastrulation and sensory cell orientation. Fz/PCP signalling depends on complex interactions between core components, leading to their asymmetric distribution and ultimately polarized activity in a cell. Whereas several mechanistic aspects of PCP have been uncovered, the global coordination of this polarization remains debated.

Original languageEnglish
Pages (from-to)126-138
Number of pages13
JournalNature Reviews Genetics
Volume8
Issue number2
DOIs
StatePublished - Feb 2007

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