Fourier transform light scattering (FTLS) of cells and tissues

Huafeng Ding; Zhuo Wang; Freddy T. Nguyen; Stephen A. Boppart; Larry J. Millet; Martha U. Gillette; Jianming Liu; Marni D. Boppart; Gabriel Popescu

doi:10.1166/jctn.2010.1637

Fourier transform light scattering (FTLS) of cells and tissues

Huafeng Ding
, Zhuo Wang
, Freddy T. Nguyen
, Stephen A. Boppart
, Larry J. Millet
, Martha U. Gillette
, Jianming Liu
, Marni D. Boppart
, Gabriel Popescu

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Fourier transform light scattering (FTLS) has been recently developed as a novel, ultrasensitive method for studying light scattering from inhomogeneous and dynamic structures. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. In this paper, we review the principle and applications of FTLS to static and dynamic light scattering from biological tissues and live cells. Compared with other existing light scattering techniques, FTLS has significant benefits of high sensitivity, speed, and angular resolution. We anticipate that FTLS will set the basis for disease diagnosis based on intrinsic tissue optical properties and provide an efficient tool for quantifying cell structures and dynamics.

Original language	English
Pages (from-to)	2501-2511
Number of pages	11
Journal	Journal of Computational and Theoretical Nanoscience
Volume	7
Issue number	12
DOIs	https://doi.org/10.1166/jctn.2010.1637
State	Published - Dec 2010
Externally published	Yes

Keywords

Cells
Fourier transform light scattering
Phase
Quantitative phase microscopy
Scattering
Tissue

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10.1166/jctn.2010.1637

Cite this

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title = "Fourier transform light scattering (FTLS) of cells and tissues",

abstract = "Fourier transform light scattering (FTLS) has been recently developed as a novel, ultrasensitive method for studying light scattering from inhomogeneous and dynamic structures. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. In this paper, we review the principle and applications of FTLS to static and dynamic light scattering from biological tissues and live cells. Compared with other existing light scattering techniques, FTLS has significant benefits of high sensitivity, speed, and angular resolution. We anticipate that FTLS will set the basis for disease diagnosis based on intrinsic tissue optical properties and provide an efficient tool for quantifying cell structures and dynamics.",

keywords = "Cells, Fourier transform light scattering, Phase, Quantitative phase microscopy, Scattering, Tissue",

author = "Huafeng Ding and Zhuo Wang and Nguyen, \{Freddy T.\} and Boppart, \{Stephen A.\} and Millet, \{Larry J.\} and Gillette, \{Martha U.\} and Jianming Liu and Boppart, \{Marni D.\} and Gabriel Popescu",

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doi = "10.1166/jctn.2010.1637",

language = "English",

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TY - JOUR

T1 - Fourier transform light scattering (FTLS) of cells and tissues

AU - Ding, Huafeng

AU - Wang, Zhuo

AU - Nguyen, Freddy T.

AU - Boppart, Stephen A.

AU - Millet, Larry J.

AU - Gillette, Martha U.

AU - Liu, Jianming

AU - Boppart, Marni D.

AU - Popescu, Gabriel

PY - 2010/12

Y1 - 2010/12

N2 - Fourier transform light scattering (FTLS) has been recently developed as a novel, ultrasensitive method for studying light scattering from inhomogeneous and dynamic structures. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. In this paper, we review the principle and applications of FTLS to static and dynamic light scattering from biological tissues and live cells. Compared with other existing light scattering techniques, FTLS has significant benefits of high sensitivity, speed, and angular resolution. We anticipate that FTLS will set the basis for disease diagnosis based on intrinsic tissue optical properties and provide an efficient tool for quantifying cell structures and dynamics.

AB - Fourier transform light scattering (FTLS) has been recently developed as a novel, ultrasensitive method for studying light scattering from inhomogeneous and dynamic structures. FTLS relies on quantifying the optical phase and amplitude associated with a coherent image field and propagating it numerically to the scattering plane. In this paper, we review the principle and applications of FTLS to static and dynamic light scattering from biological tissues and live cells. Compared with other existing light scattering techniques, FTLS has significant benefits of high sensitivity, speed, and angular resolution. We anticipate that FTLS will set the basis for disease diagnosis based on intrinsic tissue optical properties and provide an efficient tool for quantifying cell structures and dynamics.

KW - Cells

KW - Fourier transform light scattering

KW - Phase

KW - Quantitative phase microscopy

KW - Scattering

KW - Tissue

UR - https://www.scopus.com/pages/publications/79955367119

U2 - 10.1166/jctn.2010.1637

DO - 10.1166/jctn.2010.1637

M3 - Review article

AN - SCOPUS:79955367119

SN - 1546-1955

VL - 7

SP - 2501

EP - 2511

JO - Journal of Computational and Theoretical Nanoscience

JF - Journal of Computational and Theoretical Nanoscience

IS - 12

ER -

Fourier transform light scattering (FTLS) of cells and tissues

Abstract

Keywords

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