Foscarnet-resistant cytomegalovirus esophagitis with stricturing

Vinaya Gaduputi, Harish Patel, Vamshidhar Vootla, Usman Khan, Sridhar Chilimuri

Research output: Contribution to journalArticlepeer-review

Abstract

We report the case of a 52-year-old man with HIV-AIDS, non-complaint with highly active antiretroviral therapy, who presented with long-standing dysphagia. He was treated for three episodes of severe Candida esophagitis with fluconazole and later caspofungin due to poor response. In spite of the prolonged treatment courses the patient did not report an improvement in his symptoms. He was also concomitantly being treated for other opportunistic infections including cytomegalovirus (CMV) retinitis with i.v. foscarnet for almost 2 months prior to the index presentation. Upper esophagogastroduodenoscopy revealed multiple superficial ulcers with stricturing. Bougie dilatation was attempted but failed. The biopsy specimens revealed multiple intracellular inclusion bodies pathognomonic of CMV infection. We aim to highlight the increasing resistance of CMV to conventional first-line antiviral agents such as foscarnet.

Original languageEnglish
Pages (from-to)25-29
Number of pages5
JournalCase Reports in Gastroenterology
Volume7
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Keywords

  • Cytomegalovirus esophagitis
  • Cytomegalovirus infection in HIV
  • Esophagitis in HIV
  • Foscarnet-resistant cytomegalovirus

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