Foscarnet-induced genital lesions: An overview with a case report

Jonas A. Adalsteinsson; Michael Pan; Shivani Kaushik; Jonathan Ungar

doi:10.4081/dr.2018.7749

Foscarnet-induced genital lesions: An overview with a case report

Jonas A. Adalsteinsson, Michael Pan, Shivani Kaushik, Jonathan Ungar

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Foscarnet is an important antiviral medication used mainly in the treatment of complicated Herpes-simplex virus and cytomegalovirus (CMV) infections. Reported first in the 1990’s, genital ulcers are a potential side effect in about 10% of cases. We report the case of a 29 year old man with acute myelogenous leukemia who was on ganciclovir for CMV prophylaxis. Three weeks after being switched to foscarnet because of neutropenia, he developed two, painful symmetric ulcers on the inferi- or aspect of glans penis. Viral and bacterial cultures were negative. Two weeks after stopping the infusion of foscarnet, the ulcers subsided without any additional treatment. It is important that physicians be aware of this potentially disfiguring side effect of foscarnet so that methods of prevention can be implemented early in the treatment of these patients.

Original language	English
Article number	7749
Journal	Dermatology Reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.4081/dr.2018.7749
State	Published - 2018
Externally published	Yes

Keywords

Foscarnet
Genital
Ulcer

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abstract = "Foscarnet is an important antiviral medication used mainly in the treatment of complicated Herpes-simplex virus and cytomegalovirus (CMV) infections. Reported first in the 1990{\textquoteright}s, genital ulcers are a potential side effect in about 10% of cases. We report the case of a 29 year old man with acute myelogenous leukemia who was on ganciclovir for CMV prophylaxis. Three weeks after being switched to foscarnet because of neutropenia, he developed two, painful symmetric ulcers on the inferi- or aspect of glans penis. Viral and bacterial cultures were negative. Two weeks after stopping the infusion of foscarnet, the ulcers subsided without any additional treatment. It is important that physicians be aware of this potentially disfiguring side effect of foscarnet so that methods of prevention can be implemented early in the treatment of these patients.",

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AU - Kaushik, Shivani

AU - Ungar, Jonathan

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AB - Foscarnet is an important antiviral medication used mainly in the treatment of complicated Herpes-simplex virus and cytomegalovirus (CMV) infections. Reported first in the 1990’s, genital ulcers are a potential side effect in about 10% of cases. We report the case of a 29 year old man with acute myelogenous leukemia who was on ganciclovir for CMV prophylaxis. Three weeks after being switched to foscarnet because of neutropenia, he developed two, painful symmetric ulcers on the inferi- or aspect of glans penis. Viral and bacterial cultures were negative. Two weeks after stopping the infusion of foscarnet, the ulcers subsided without any additional treatment. It is important that physicians be aware of this potentially disfiguring side effect of foscarnet so that methods of prevention can be implemented early in the treatment of these patients.

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Foscarnet-induced genital lesions: An overview with a case report

Abstract

Keywords

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