@article{9f4585aeb4af4f9bb4b1d6cc3826b5ea,
title = "Formation and maintenance of Alzheimer's disease β-amyloid plaques in the absence of microglia",
abstract = "In Alzheimer's disease, microglia cluster around β-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor amyloid-associated neuritic dystrophy depended on the presence of microglia.",
author = "Grathwohl, \{Stefan A.\} and K{\"a}lin, \{Roland E.\} and Tristan Bolmont and Stefan Prokop and Georg Winkelmann and Kaeser, \{Stephan A.\} and J{\"o}rg Odenthal and Rebecca Radde and Therese Eldh and Sam Gandy and Adriano Aguzzi and Matthias Staufenbiel and Mathews, \{Paul M.\} and Hartwig Wolburg and Heppner, \{Frank L.\} and Mathias Jucker",
note = "Funding Information: This work was supported by grants to M.J. (BMBF-01GI0705), F.L.H. (SFB-TR43, Exc 25 and National Institutes of Neurological Disorders and Stroke R01 NS046006) and P.M.M. (US National Institutes of Health AG017617 and NS045205). AUTHOR CONTRIBUTIONS S.A.G., T.B., S.A.K., J.O., R.R., T.E., P.M.M. and H.W. performed the icv experiments. R.E.K., S.P. and G.W. carried out the oral treatment experiments. A.A., M.S. and S.G. provided mice and/or advice. Experimental design and manuscript preparation were mainly carried out by F.L.H. and M.J.",
year = "2009",
month = nov,
doi = "10.1038/nn.2432",
language = "English",
volume = "12",
pages = "1361--1363",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Research",
number = "11",
}