@article{651f0f4619fc4661bfbb131a97fd501b,
title = "Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens",
abstract = "ImmunoglobulinA (IgA) is the predominant antibody isotype in the gut, where it regulates commensal flora and neutralizes toxins and pathogens. The function of food-specific IgA in the gut is unknown but is presumed to protect from food allergy. Specifically, it has been hypothesized that food-specific IgA binds ingested allergens and promotes tolerance by immune exclusion; however, the evidence to support this hypothesis is indirect and mixed. Although it is known that healthy adults have peanut-specific IgA in the gut, it is unclear whether children also have gut peanut-specific IgA. We found in a cohort of non-food-allergic infants (n = 112) that there is detectable stool peanut-specific IgA that is similar to adult quantities of gut peanut-specific IgA. To investigate whether this peanut-specific IgA is associated with peanut tolerance, we examined a separate cohort of atopic children (n = 441) and found that gut peanut-specific IgA does not predict protection from development of future peanut allergy in infants nor does it correlate with concurrent oral tolerance of peanut in older children. We observed higher plasma peanut-specific IgA in those with peanut allergy. Similarly, egg white-specific IgA was detectable in infant stools and did not predict egg tolerance or outgrowth of egg allergy. Bead-based epitope assay analysis of gut peanut-specific IgA revealed similar epitope specificity between children with peanut allergy and those without; however, gut peanut-specific IgA and plasma peanut-specific IgE had different epitope specificities. These findings call into question the presumed protective role of food-specific IgA in food allergy.",
author = "Liu, {Elise G.} and Biyan Zhang and Victoria Martin and John Anthonypillai and Magdalena Kraft and Alexander Grishin and Galina Grishina and Catanzaro, {Jason R.} and Sharon Chinthrajah and Tina Sindher and Monali Manohar and Quake, {Antonia Zoe} and Kari Nadeau and {Wesley Burks}, A. and Kim, {Edwin H.} and Kulis, {Michael D.} and Henning, {Alice K.} and Jones, {Stacie M.} and Leung, {Donald Y.M.} and Sicherer, {Scott H.} and Wood, {Robert A.} and Qian Yuan and Wayne Shreffler and Hugh Sampson and Veronika Shabanova and Eisenbarth, {Stephanie C.}",
note = "Funding Information: Acknowledgments:W eacknowledgeallthepatientsandfamilieswhoparticipatedinthe CoFAR2study,GMAPstudy,POISEDtrial,andStanfordTwinRegistry.W ethankM.Plaut,CoFAR scientific and medical officer. In addition, we are grateful to the staff of the clinical research unitsateachCoFAR2siteandtheStatisticalandClinicalCoordinatingCenterforCoFAR2.W e thankK.Jarvinen-Seppoforthoughtfuldiscussionandhelpwithassays.W earegratefulforthe supportanddiscussionfromthemembersoftheEisenbarthLab.W eacknowledgetheGerber FoundationandtheDemarestLloydJr.FoundationforsupportoftheGMAPstudy.Funding: E.G.L.issupportedbyaT32InstitutionalTr aining Grant(5T32AR007107).V .M. issupportedbya K23awardfromtheNationalInstituteofAllergyandInfectiousDiseases(NIAID)oftheU.S. NationalInstitutesofHealth(NIH)(1K23AI151555-01A1).M.K.issupportedbyafellowshipfrom theGermanResearchFoundation(464546188;KR5534/1-1).S.C.E.issupportedbytheIra& DianaRiklisFoodAllergyResearchA wardfromFoodAllergyResearchandEducation(FARE),the SeanN.ParkerCenterforAllergyandAsthmaResearch,theColtonFoundation,agrantfromthe Publisher Copyright: Copyright {\textcopyright} 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.",
year = "2022",
month = nov,
day = "16",
doi = "10.1126/scitranslmed.abq0599",
language = "English",
volume = "14",
journal = "Science Translational Medicine",
issn = "1946-6234",
publisher = "American Association for the Advancement of Science",
number = "671",
}