Food protein-induced enterocolitis syndrome: Epidemiology and comorbidities

Mary Grace Baker, Anna Nowak-Wegrzyn

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations


Purpose of reviewFirst described in the mid 20th century, it was just in the last decade that diagnostic and treatment guidelines for food protein-induced enterocolitis syndrome (FPIES) were established. Awareness of the diagnosis is improving, and epidemiologic data are emerging.Recent findingsRecent studies suggest that FPIES may affect as many as 0.5% of children worldwide. FPIES in adults is usually triggered by seafood and may be more common than previously thought. Many patients with FPIES have other allergic disorders.SummaryWith refined diagnostic criteria and improved awareness, FPIES is now diagnosed with increasing frequency, and epidemiologic data are emerging. FPIES appears to be increasing in prevalence, and the frequent association with other allergic disorders suggests a shared predisposition or immune mechanism that remains to be elucidated.

Original languageEnglish
Pages (from-to)168-174
Number of pages7
JournalCurrent Opinion in Allergy and Clinical Immunology
Issue number2
StatePublished - 1 Apr 2020


  • food allergy
  • food hypersensitivity
  • food intolerance
  • food protein-induced enterocolitis syndrome


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