TY - JOUR
T1 - Food Protein-Induced Enterocolitis Syndrome, Allergic Proctocolitis, and Enteropathy
AU - Feuille, Elizabeth
AU - Nowak-Węgrzyn, Anna
N1 - Publisher Copyright:
© 2015, Springer Science+Business Media New York.
PY - 2015/8/25
Y1 - 2015/8/25
N2 - Food protein-induced enterocolitis (FPIES), allergic proctocolitis (FPIAP), and enteropathy (FPE) are among a number of immune-mediated reactions to food that are thought to occur primarily via non-IgE-mediated pathways. All three are typically present in infancy and are triggered most commonly by cow’s milk protein. The usual presenting features are vomiting with lethargy and dehydration in FPIES; bloody and mucous stools in FPIAP; and diarrhea with malabsorption and failure to thrive in FPE. Diagnosis is based on convincing history and resolution of symptoms with food avoidance; confirmatory diagnostic testing other than food challenge is lacking. The mainstay of management is avoidance of the suspected inciting food, with interval challenge to assess for resolution, which usually occurs in the first years of life. Studies published in the past few years clarify common presenting features, report additional culprit foods, address potential biomarkers, and suggest new management strategies.
AB - Food protein-induced enterocolitis (FPIES), allergic proctocolitis (FPIAP), and enteropathy (FPE) are among a number of immune-mediated reactions to food that are thought to occur primarily via non-IgE-mediated pathways. All three are typically present in infancy and are triggered most commonly by cow’s milk protein. The usual presenting features are vomiting with lethargy and dehydration in FPIES; bloody and mucous stools in FPIAP; and diarrhea with malabsorption and failure to thrive in FPE. Diagnosis is based on convincing history and resolution of symptoms with food avoidance; confirmatory diagnostic testing other than food challenge is lacking. The mainstay of management is avoidance of the suspected inciting food, with interval challenge to assess for resolution, which usually occurs in the first years of life. Studies published in the past few years clarify common presenting features, report additional culprit foods, address potential biomarkers, and suggest new management strategies.
KW - Allergic colitis
KW - Allergic enterocolitis
KW - Allergic proctocolitis
KW - FPE
KW - FPIAP
KW - FPIES
KW - Food allergy
KW - Food protein-induced allergic proctocolitis
KW - Food protein-induced enterocolitis
KW - Food protein-induced enteropathy
UR - http://www.scopus.com/inward/record.url?scp=84937923583&partnerID=8YFLogxK
U2 - 10.1007/s11882-015-0546-9
DO - 10.1007/s11882-015-0546-9
M3 - Review article
C2 - 26174434
AN - SCOPUS:84937923583
SN - 1529-7322
VL - 15
JO - Current Allergy and Asthma Reports
JF - Current Allergy and Asthma Reports
IS - 8
M1 - 50
ER -