Food Allergy: Emerging Therapies

Ashna Mehra, Rebecca Grohman, Sohini Shah, Anna Nowak-Węgrzyn

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Purpose of Review: The purpose of this review is to discuss the current and emerging treatment options of food allergy. Recent Findings: The mainstay of treatment for food allergy was traditionally avoidance and/or symptomatic antihistamine and adrenaline treatment depending on severity of symptoms. In the past two decades, allergen-specific immunotherapy and biologic therapies have emerged as treatment options to increase the threshold of reactivity to specific food allergens. Allergen-specific approaches include oral, sublingual, subcutaneous, and epicutaneous immunotherapy as well as DNA vaccines. Monoclonal antibodies blocking IgE and IL-4/IL-13 receptors are being investigated as monotherapy and as combined therapy with allergen specific immunotherapy. Summary: While oral immunotherapy is best studied and has led to an FDA approved therapy for patients between 4 and 17 years old (Palforzia™), many of the other immunotherapies as well as biologics are still in early stages of clinical trials.

Original languageEnglish
Pages (from-to)319-339
Number of pages21
JournalCurrent Treatment Options in Allergy
Volume10
Issue number3
DOIs
StatePublished - Sep 2023
Externally publishedYes

Keywords

  • Allergen
  • Food allergy
  • Immunotherapy

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