Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB

Cees E. van der Poel; Goran Bajic; Charles W. Macaulay; Theo van den Broek; Christian D. Ellson; Gerben Bouma; Gabriel D. Victora; Søren E. Degn; Michael C. Carroll

doi:10.1016/j.celrep.2019.10.086

Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB

Cees E. van der Poel
, Goran Bajic
, Charles W. Macaulay
, Theo van den Broek
, Christian D. Ellson
, Gerben Bouma
, Gabriel D. Victora
, Søren E. Degn
, Michael C. Carroll

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

van der Poel et al. show that follicular dendritic cells (FDCs) can regulate germinal center diversity through FcγRIIB. In the absence of this receptor, germinal centers appear more diverse. In addition, the loss of FcγRIIB on FDCs leads to the persistence of IgM clones with decreased levels of somatic hypermutation.

Original language	English
Pages (from-to)	2745-2755.e4
Journal	Cell Reports
Volume	29
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2019.10.086
State	Published - 26 Nov 2019
Externally published	Yes

Keywords

CD32
FcγRIIB
autoimmunity
clonal selection
follicular dendritic cells
germinal center

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10.1016/j.celrep.2019.10.086

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@article{39fee1ed2c7c40a6be48d9d7996db90c,

title = "Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB",

abstract = "van der Poel et al. show that follicular dendritic cells (FDCs) can regulate germinal center diversity through FcγRIIB. In the absence of this receptor, germinal centers appear more diverse. In addition, the loss of FcγRIIB on FDCs leads to the persistence of IgM clones with decreased levels of somatic hypermutation.",

keywords = "CD32, FcγRIIB, autoimmunity, clonal selection, follicular dendritic cells, germinal center",

author = "\{van der Poel\}, \{Cees E.\} and Goran Bajic and Macaulay, \{Charles W.\} and \{van den Broek\}, Theo and Ellson, \{Christian D.\} and Gerben Bouma and Victora, \{Gabriel D.\} and Degn, \{S{\o}ren E.\} and Carroll, \{Michael C.\}",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = nov,

day = "26",

doi = "10.1016/j.celrep.2019.10.086",

language = "English",

volume = "29",

pages = "2745--2755.e4",

journal = "Cell Reports",

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TY - JOUR

T1 - Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB

AU - van der Poel, Cees E.

AU - Bajic, Goran

AU - Macaulay, Charles W.

AU - van den Broek, Theo

AU - Ellson, Christian D.

AU - Bouma, Gerben

AU - Victora, Gabriel D.

AU - Degn, Søren E.

AU - Carroll, Michael C.

PY - 2019/11/26

Y1 - 2019/11/26

N2 - van der Poel et al. show that follicular dendritic cells (FDCs) can regulate germinal center diversity through FcγRIIB. In the absence of this receptor, germinal centers appear more diverse. In addition, the loss of FcγRIIB on FDCs leads to the persistence of IgM clones with decreased levels of somatic hypermutation.

AB - van der Poel et al. show that follicular dendritic cells (FDCs) can regulate germinal center diversity through FcγRIIB. In the absence of this receptor, germinal centers appear more diverse. In addition, the loss of FcγRIIB on FDCs leads to the persistence of IgM clones with decreased levels of somatic hypermutation.

KW - CD32

KW - FcγRIIB

KW - autoimmunity

KW - clonal selection

KW - follicular dendritic cells

KW - germinal center

UR - https://www.scopus.com/pages/publications/85075471163

U2 - 10.1016/j.celrep.2019.10.086

DO - 10.1016/j.celrep.2019.10.086

M3 - Article

C2 - 31775042

AN - SCOPUS:85075471163

SN - 2639-1856

VL - 29

SP - 2745-2755.e4

JO - Cell Reports

JF - Cell Reports

IS - 9

ER -

Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB

Abstract

Keywords

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