Folate biochemical modulation regimen for the treatment of gastric cancer

Twenty patients with metastatic gastric cancer were treated with methotrexate (MTX, M), 100 to 160 mg/m² at 0 h, and, in sequence, 5-fluorouracil (FU, F), 600 to 1000 mg/m² at 4 h; leucovorin (LV, L), 200 mg/m² at 18 h, then 20 mg/m² every 6 h × 12; 5-fluorouracil, 600 mg/m² at 19 h; and high-dose cisplatin (DDP, P), 100 mg/m² at 20 h. In addition, they were treated with a continuous 5-fluorouracil infusion, 1000 mg/m²/24 h from 18 h to 114. There were 8 complete and 6 partial responses among the 16 patients with measurable tumors. Five patients, each with one remaining clinical site of disease, received supplementary regional therapy: three received intraperitoneal therapy, two received hepatic arterial therapy. Intraperitoneal therapy and hepatic artery therapy each produced one complete response. Median survival was 16 months for all patients, and 25% survived 2 years. In comparison with matched patients, both response rates and survival improved twofold.