@article{273974bac20d44da84c07be47cca8e5d,
title = "Focal Gains of VEGFA: Candidate Predictors of Sorafenib Response in Hepatocellular Carcinoma",
abstract = "Focal amplifications in 6p21 containing the VEGFA locus occur in 7%-10% of hepatocellular carcinoma (HCC). A recent paper describes how VEGF-A stimulates paracrine secretion of hepatocyte growth factor by stromal cells, which induces tumor progression. HCC patients with VEGFA amplification are distinctly sensitive to sorafenib.",
author = "Llovet, {Josep M.}",
note = "Funding Information: J.M.L. has grants from NIH-NIDDK (1R01DK076986-01), National Institute of Health (Spain) I+D Program (SAF-2010-16055), the Samuel Waxman Cancer Research Foundation, the European Commission Framework Programme 7 (Heptromic, proposal number 259744), and the Asociaci{\'o}n Espa{\~n}ola para el Estudio del C{\'a}ncer. ",
year = "2014",
month = may,
day = "12",
doi = "10.1016/j.ccr.2014.04.019",
language = "English",
volume = "25",
pages = "560--562",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "5",
}