Focal Gains of VEGFA: Candidate Predictors of Sorafenib Response in Hepatocellular Carcinoma

Research output: Contribution to journalShort surveypeer-review

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Abstract

Focal amplifications in 6p21 containing the VEGFA locus occur in 7%-10% of hepatocellular carcinoma (HCC). A recent paper describes how VEGF-A stimulates paracrine secretion of hepatocyte growth factor by stromal cells, which induces tumor progression. HCC patients with VEGFA amplification are distinctly sensitive to sorafenib.

Original languageEnglish
Pages (from-to)560-562
Number of pages3
JournalCancer Cell
Volume25
Issue number5
DOIs
StatePublished - 12 May 2014

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