Focal adhesion kinase and its role in skeletal muscle

Zachary A. Graham, Philip M. Gallagher, Christopher P. Cardozo

Research output: Contribution to journalReview articlepeer-review

85 Scopus citations

Abstract

Skeletal muscle has a remarkable ability to respond to different physical stresses. Loading muscle through exercise, either anaerobic or aerobic, can lead to increases in muscle size and function while, conversely, the absence of muscle loading stimulates rapid decreases in size and function. A principal mediator of this load-induced change is focal adhesion kinase (FAK), a downstream non-receptor tyrosine kinase that translates the cytoskeletal stress and strain signals transmitted across the cytoplasmic membrane by integrins to activate multiple anti-apoptotic and cell growth pathways. Changes in FAK expression and phosphorylation have been found to correlate to specific developmental states in myoblast differentiation, muscle fiber formation and muscle size in response to loading and unloading. With the capability to regulate costamere formation, hypertrophy and glucose metabolism, FAK is a molecule with diverse functions that are important in regulating muscle cell health.

Original languageEnglish
Pages (from-to)305-315
Number of pages11
JournalJournal of Muscle Research and Cell Motility
Volume36
Issue number4-5
DOIs
StatePublished - 1 Oct 2015

Keywords

  • Exercise
  • Focal adhesion kinase
  • Hypertrophy
  • Muscle development

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