Fluorophotometric determination of the corneal epithelial barrier after penetrating keratoplasty

Richard A. Berkowitz; Stephen D. Klyce; John D. Salisbury; Herbert E. Kaufman

doi:10.1016/0002-9394(81)90521-3

Fluorophotometric determination of the corneal epithelial barrier after penetrating keratoplasty

Richard A. Berkowitz, Stephen D. Klyce, John D. Salisbury, Herbert E. Kaufman

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

We measured the magnitude and the range of increased penetrance of fluorescein into the human cornea and anterior chamber in the first week after penetrating keratoplasty. Healed corneal transplants showed a permeability 3.3 times that of normal eyes that had not undergone surgery. Partially healed corneal transplants showed a permeability 67 times that of the control eyes and 20 times that of the healed transplants. Such increased permeabilities may have important implications in the adjustment of dosages of topically applied ophthalmic drugs in relation to expected therapeutic results and possible ocular and systemic side effects.

Original language	English
Pages (from-to)	332-335
Number of pages	4
Journal	American Journal of Ophthalmology
Volume	92
Issue number	3
DOIs	https://doi.org/10.1016/0002-9394(81)90521-3
State	Published - Sep 1981
Externally published	Yes

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title = "Fluorophotometric determination of the corneal epithelial barrier after penetrating keratoplasty",

abstract = "We measured the magnitude and the range of increased penetrance of fluorescein into the human cornea and anterior chamber in the first week after penetrating keratoplasty. Healed corneal transplants showed a permeability 3.3 times that of normal eyes that had not undergone surgery. Partially healed corneal transplants showed a permeability 67 times that of the control eyes and 20 times that of the healed transplants. Such increased permeabilities may have important implications in the adjustment of dosages of topically applied ophthalmic drugs in relation to expected therapeutic results and possible ocular and systemic side effects.",

author = "Berkowitz, \{Richard A.\} and Klyce, \{Stephen D.\} and Salisbury, \{John D.\} and Kaufman, \{Herbert E.\}",

note = "Funding Information: From the Lions Eye Research Laboratories, LSU Eye Center, LSU Medical Center School of Medicine, New Orleans, Louisiana. This study was supported in part by grants EY03311 (Dr. Klyce), EY02580 (Dr. Kaufman), and EY02377 (Dr. Kaufman) from the National Eye Institute, and a postdoctoral fellowship from Fight for Sight, Inc. (Dr. Berkowitz).",

year = "1981",

month = sep,

doi = "10.1016/0002-9394(81)90521-3",

language = "English",

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pages = "332--335",

journal = "American Journal of Ophthalmology",

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T1 - Fluorophotometric determination of the corneal epithelial barrier after penetrating keratoplasty

AU - Berkowitz, Richard A.

AU - Klyce, Stephen D.

AU - Salisbury, John D.

AU - Kaufman, Herbert E.

N1 - Funding Information: From the Lions Eye Research Laboratories, LSU Eye Center, LSU Medical Center School of Medicine, New Orleans, Louisiana. This study was supported in part by grants EY03311 (Dr. Klyce), EY02580 (Dr. Kaufman), and EY02377 (Dr. Kaufman) from the National Eye Institute, and a postdoctoral fellowship from Fight for Sight, Inc. (Dr. Berkowitz).

PY - 1981/9

Y1 - 1981/9

N2 - We measured the magnitude and the range of increased penetrance of fluorescein into the human cornea and anterior chamber in the first week after penetrating keratoplasty. Healed corneal transplants showed a permeability 3.3 times that of normal eyes that had not undergone surgery. Partially healed corneal transplants showed a permeability 67 times that of the control eyes and 20 times that of the healed transplants. Such increased permeabilities may have important implications in the adjustment of dosages of topically applied ophthalmic drugs in relation to expected therapeutic results and possible ocular and systemic side effects.

AB - We measured the magnitude and the range of increased penetrance of fluorescein into the human cornea and anterior chamber in the first week after penetrating keratoplasty. Healed corneal transplants showed a permeability 3.3 times that of normal eyes that had not undergone surgery. Partially healed corneal transplants showed a permeability 67 times that of the control eyes and 20 times that of the healed transplants. Such increased permeabilities may have important implications in the adjustment of dosages of topically applied ophthalmic drugs in relation to expected therapeutic results and possible ocular and systemic side effects.

UR - https://www.scopus.com/pages/publications/0019439440

U2 - 10.1016/0002-9394(81)90521-3

DO - 10.1016/0002-9394(81)90521-3

M3 - Article

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AN - SCOPUS:0019439440

SN - 0002-9394

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SP - 332

EP - 335

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

IS - 3

ER -

Fluorophotometric determination of the corneal epithelial barrier after penetrating keratoplasty

Abstract

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