Flow-Responsive Noncoding RNAs in the Vascular System: Basic Mechanisms for the Clinician

Salvatore De Rosa, Claudio Iaconetti, Ceren Eyileten, Masakazu Yasuda, Michele Albanese, Alberto Polimeni, Jolanda Sabatino, Sabato Sorrentino, Marek Postula, Ciro Indolfi

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations


The vascular system is largely exposed to the effect of changing flow conditions. Vascular cells can sense flow and its changes. Flow sensing is of pivotal importance for vascular remodeling. In fact, it influences the development and progression of atherosclerosis, controls its location and has a major influx on the development of local complications. Despite its importance, the research community has traditionally paid scarce attention to studying the association between different flow conditions and vascular biology. More recently, a growing body of evidence has been accumulating, revealing that ncRNAs play a key role in the modulation of several biological processes linking flow-sensing to vascular pathophysiology. This review summarizes the most relevant evidence on ncRNAs that are directly or indirectly responsive to flow conditions to the benefit of the clinician, with a focus on the underpinning mechanisms and their potential application as disease biomarkers.

Original languageEnglish
Article number459
JournalJournal of Clinical Medicine
Issue number2
StatePublished - 1 Jan 2022
Externally publishedYes


  • Biomarkers
  • Flow
  • MicroRNAs
  • Noncoding RNAs
  • Shear stress
  • Vascular remodeling


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