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Flow cytometric identification of tumor-infiltrating lymphocytes from glioblastoma

  • Karolina Woroniecka
  • , Pakawat Chongsathidkiet
  • , Aladine Elsamadicy
  • , Harrison Farber
  • , Xiuyu Cui
  • , Peter E. Fecci

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

9 Scopus citations

Abstract

We describe an isolation method of tumor-infiltrating lymphocytes (TILs) from glioblastoma tumors for the purpose of analysis by flow cytometry. This protocol is unique from many others in that the use of a selective lymphocyte isolation procedure, such as a Ficoll or Percoll gradient, is not used. We find that staining of TILs and analysis by flow cytometry is not affected by the presence of heterogeneous populations, while other selective isolation procedures can significantly decrease lymphocyte yield from already rare populations.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages221-226
Number of pages6
DOIs
StatePublished - 2018
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1741
ISSN (Print)1064-3745

Keywords

  • Brain tumor
  • Flow cytometry
  • Stomacher
  • Tumor-infiltrating lymphocyte (TIL) isolation

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