Flow as a regulator of the activation of factor X by tissue factor

C. H. Gemmell, V. T. Turitto, Y. Nemerson

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

A novel enzyme reactor for phospholipid-dependent reactions was used to study the effects of flow on tissue factor-initiated coagulation. Microcapillaries were coated with a phospholipid bilayer containing tissue factor, a transmembrane protein that is an essential cofactor for a plasma procoagulant enzyme, factor VII. We show that, in contrast to static, closed systems, the steady-state catalytic activity is independent of enzyme concentration and the time to steady state becomes a function of the enzyme concentration.

Original languageEnglish
Pages (from-to)1404-1406
Number of pages3
JournalBlood
Volume72
Issue number4
DOIs
StatePublished - 1988
Externally publishedYes

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