Flavivirus modulation of cellular metabolism

Tristan X. Jordan, Glenn Randall

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Over the last decade, we have begun to appreciate how flaviviruses manipulate cellular metabolism to establish an optimal environment for their replication. These metabolic changes include the stimulation of glycolysis, in addition to lipid anabolic and catabolic pathways. These processes are thought to promote an energetically favorable state, in addition to modifying membrane lipid composition for viral replication and virion envelopment. Importantly, many of these processes can be pharmacologically inhibited as successful antiviral strategies, at least in cell culture. In this review, we discuss the mechanisms by which flaviviruses alter cellular metabolism, remaining questions, and opportunities for therapeutic development.

Original languageEnglish
Pages (from-to)7-10
Number of pages4
JournalCurrent Opinion in Virology
Volume19
DOIs
StatePublished - 1 Aug 2016
Externally publishedYes

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