Flare of Crohn's disease in a patient receiving chronic tacrolimus therapy: A case report and literature review

Robin B. Forman; Petros Benias; Tamer N. Sargios; Brett B. Bernstein; Henry C. Bodenheimer

Flare of Crohn's disease in a patient receiving chronic tacrolimus therapy: A case report and literature review

Robin B. Forman, Petros Benias, Tamer N. Sargios, Brett B. Bernstein, Henry C. Bodenheimer

Research output: Contribution to journal › Article › peer-review

Abstract

We report a case of Crohn's disease (CD) of new onset in a patient being treated with tacrolimus for the prevention of renal allograft rejection. Tacrolimus is a calcineurin inhibitor used as a first-line immunosuppressive drug in organ transplant recipients to prevent allograft rejection. Recent reports also suggest a role for the drug in the treatment of CD. This case reports the onset of CD in a patient already on a potent immunosuppressive regimen. Such cases of new onset CD and CD refractory to immunosuppressive therapy support the idea that the pathogenicity of this disease is multifactorial involving multiple arms of the immune response.

Original language	English
Pages (from-to)	70-78
Number of pages	9
Journal	Practical Gastroenterology
Volume	30
Issue number	11
State	Published - Nov 2006
Externally published	Yes

Cite this

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title = "Flare of Crohn's disease in a patient receiving chronic tacrolimus therapy: A case report and literature review",

abstract = "We report a case of Crohn's disease (CD) of new onset in a patient being treated with tacrolimus for the prevention of renal allograft rejection. Tacrolimus is a calcineurin inhibitor used as a first-line immunosuppressive drug in organ transplant recipients to prevent allograft rejection. Recent reports also suggest a role for the drug in the treatment of CD. This case reports the onset of CD in a patient already on a potent immunosuppressive regimen. Such cases of new onset CD and CD refractory to immunosuppressive therapy support the idea that the pathogenicity of this disease is multifactorial involving multiple arms of the immune response.",

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T2 - A case report and literature review

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AU - Benias, Petros

AU - Sargios, Tamer N.

AU - Bernstein, Brett B.

AU - Bodenheimer, Henry C.

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N2 - We report a case of Crohn's disease (CD) of new onset in a patient being treated with tacrolimus for the prevention of renal allograft rejection. Tacrolimus is a calcineurin inhibitor used as a first-line immunosuppressive drug in organ transplant recipients to prevent allograft rejection. Recent reports also suggest a role for the drug in the treatment of CD. This case reports the onset of CD in a patient already on a potent immunosuppressive regimen. Such cases of new onset CD and CD refractory to immunosuppressive therapy support the idea that the pathogenicity of this disease is multifactorial involving multiple arms of the immune response.

AB - We report a case of Crohn's disease (CD) of new onset in a patient being treated with tacrolimus for the prevention of renal allograft rejection. Tacrolimus is a calcineurin inhibitor used as a first-line immunosuppressive drug in organ transplant recipients to prevent allograft rejection. Recent reports also suggest a role for the drug in the treatment of CD. This case reports the onset of CD in a patient already on a potent immunosuppressive regimen. Such cases of new onset CD and CD refractory to immunosuppressive therapy support the idea that the pathogenicity of this disease is multifactorial involving multiple arms of the immune response.

UR - https://www.scopus.com/pages/publications/33845236632

M3 - Article

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JO - Practical Gastroenterology

JF - Practical Gastroenterology

IS - 11

ER -

Flare of Crohn's disease in a patient receiving chronic tacrolimus therapy: A case report and literature review

Abstract

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