Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: A prospective cohort study

Tao Huang; Tiange Wang; Yoriko Heianza; Janey Wiggs; Dianjianyi Sun; Hyon Kyoo Choi; Jin Fang Chai; Xueling Sim; Chiea Chuen Khor; Yechiel Friedlander; Andrew T. Chan; Gary Curhan; Immaculata De Vivo; Rob Martinu Van Dam; Chew Kiat Heng; Charles Fuchs; Louis R. Pasquale; Jian Min Yuan; Frank B. Hu; Woon Puay Koh; Lu Qi

doi:10.1136/bmjopen-2018-022877

Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: A prospective cohort study

Tao Huang
, Tiange Wang
, Yoriko Heianza
, Janey Wiggs
, Dianjianyi Sun
, Hyon Kyoo Choi
, Jin Fang Chai
, Xueling Sim
, Chiea Chuen Khor
, Yechiel Friedlander
, Andrew T. Chan
, Gary Curhan
, Immaculata De Vivo
, Rob Martinu Van Dam
, Chew Kiat Heng
, Charles Fuchs
, Louis R. Pasquale
, Jian Min Yuan
, Frank B. Hu
, Woon Puay Koh

Lu Qi

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Objective: We tested whether genetic variants near fatty acid desaturases gene (FADS) cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI). Design: Three FADS variants were examined for gene-diet interactions on long-term (∼10 years) changes in BMI and body weight in four prospective cohort studies. Setting: Population based study. Participants: 11 323 women from the Nurses' Health Study (NHS), 6833 men from the Health Professionals Follow-up Study (HPFS) and replicated in 6254 women from the Women's Health Initiative (WHI) and 5 264 Chinese from the Singapore Chinese Health Study (SCHS). Main outcomes: Long-term (∼10 years) changes in BMI and body weight. Results: In the NHS and HPFS cohorts, food-sourced n-3 PUFAs intake showed interactions with the FADS rs174570 on changes of BMI (P for interaction=0.02 in NHS, 0.05 in HPFS and 0.007 in combined). Such interactions were replicated in two independent cohorts WHI and SCHS (P for interaction=0.04 in WHI, 0.02 in SCHS and 0.001 in combined). The genetic associations of the FADS rs174570 with changes in BMI increased across the tertiles of n-3 PUFAs in all the cohorts. Fish intake also accentuated the genetic associations of the FADS rs174570 with long-term changes in BMI (pooled P for interaction=0.006). Viewed differently, long chain n-3 PUFAs intake showed stronger association with long-term changes in BMI among the rs174570 T carriers (beta=0.79 kg/m² per g, p=3×10^-5) than the rs174570 non-T carriers (beta=0.16 kg/m² per g, p=0.08). Similar results were observed for fish intake. Conclusions: Our hypothesis-driven analyses provide replicable evidence that long chain n-3 PUFAs and fish intakes may interact with the FADS variant on long-term weight gain. Further investigation is needed to confirm our findings in other cohorts.

Original language	English
Article number	e022877
Journal	BMJ Open
Volume	9
Issue number	7
DOIs	https://doi.org/10.1136/bmjopen-2018-022877
State	Published - 1 Jul 2019
Externally published	Yes

Keywords

epidemiology
gene-diet interaction
genetics
obesity

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10.1136/bmjopen-2018-022877

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Huang, T., Wang, T., Heianza, Y., Wiggs, J., Sun, D., Choi, H. K., Chai, J. F., Sim, X., Khor, C. C., Friedlander, Y., Chan, A. T., Curhan, G., De Vivo, I., Van Dam, R. M., Heng, C. K., Fuchs, C., Pasquale, L. R., Yuan, J. M., Hu, F. B., ... Qi, L. (2019). Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: A prospective cohort study. BMJ Open, 9(7), Article e022877. https://doi.org/10.1136/bmjopen-2018-022877

@article{6a4d968af5984cdfa4a6e6cf1211ca63,

title = "Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: A prospective cohort study",

abstract = "Objective: We tested whether genetic variants near fatty acid desaturases gene (FADS) cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI). Design: Three FADS variants were examined for gene-diet interactions on long-term (∼10 years) changes in BMI and body weight in four prospective cohort studies. Setting: Population based study. Participants: 11 323 women from the Nurses' Health Study (NHS), 6833 men from the Health Professionals Follow-up Study (HPFS) and replicated in 6254 women from the Women's Health Initiative (WHI) and 5 264 Chinese from the Singapore Chinese Health Study (SCHS). Main outcomes: Long-term (∼10 years) changes in BMI and body weight. Results: In the NHS and HPFS cohorts, food-sourced n-3 PUFAs intake showed interactions with the FADS rs174570 on changes of BMI (P for interaction=0.02 in NHS, 0.05 in HPFS and 0.007 in combined). Such interactions were replicated in two independent cohorts WHI and SCHS (P for interaction=0.04 in WHI, 0.02 in SCHS and 0.001 in combined). The genetic associations of the FADS rs174570 with changes in BMI increased across the tertiles of n-3 PUFAs in all the cohorts. Fish intake also accentuated the genetic associations of the FADS rs174570 with long-term changes in BMI (pooled P for interaction=0.006). Viewed differently, long chain n-3 PUFAs intake showed stronger association with long-term changes in BMI among the rs174570 T carriers (beta=0.79 kg/m2 per g, p=3×10-5) than the rs174570 non-T carriers (beta=0.16 kg/m2 per g, p=0.08). Similar results were observed for fish intake. Conclusions: Our hypothesis-driven analyses provide replicable evidence that long chain n-3 PUFAs and fish intakes may interact with the FADS variant on long-term weight gain. Further investigation is needed to confirm our findings in other cohorts.",

keywords = "epidemiology, gene-diet interaction, genetics, obesity",

author = "Tao Huang and Tiange Wang and Yoriko Heianza and Janey Wiggs and Dianjianyi Sun and Choi, \{Hyon Kyoo\} and Chai, \{Jin Fang\} and Xueling Sim and Khor, \{Chiea Chuen\} and Yechiel Friedlander and Chan, \{Andrew T.\} and Gary Curhan and \{De Vivo\}, Immaculata and \{Van Dam\}, \{Rob Martinu\} and Heng, \{Chew Kiat\} and Charles Fuchs and Pasquale, \{Louis R.\} and Yuan, \{Jian Min\} and Hu, \{Frank B.\} and Koh, \{Woon Puay\} and Lu Qi",

note = "Publisher Copyright: {\textcopyright} 2019 Author(s).",

year = "2019",

month = jul,

day = "1",

doi = "10.1136/bmjopen-2018-022877",

language = "English",

volume = "9",

journal = "BMJ Open",

issn = "2044-6055",

publisher = "BMJ Publishing Group",

number = "7",

}

Huang, T, Wang, T, Heianza, Y, Wiggs, J, Sun, D, Choi, HK, Chai, JF, Sim, X, Khor, CC, Friedlander, Y, Chan, AT, Curhan, G, De Vivo, I, Van Dam, RM, Heng, CK, Fuchs, C, Pasquale, LR, Yuan, JM, Hu, FB, Koh, WP & Qi, L 2019, 'Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: A prospective cohort study', BMJ Open, vol. 9, no. 7, e022877. https://doi.org/10.1136/bmjopen-2018-022877

TY - JOUR

T1 - Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain

T2 - A prospective cohort study

AU - Huang, Tao

AU - Wang, Tiange

AU - Heianza, Yoriko

AU - Wiggs, Janey

AU - Sun, Dianjianyi

AU - Choi, Hyon Kyoo

AU - Chai, Jin Fang

AU - Sim, Xueling

AU - Khor, Chiea Chuen

AU - Friedlander, Yechiel

AU - Chan, Andrew T.

AU - Curhan, Gary

AU - De Vivo, Immaculata

AU - Van Dam, Rob Martinu

AU - Heng, Chew Kiat

AU - Fuchs, Charles

AU - Pasquale, Louis R.

AU - Yuan, Jian Min

AU - Hu, Frank B.

AU - Koh, Woon Puay

AU - Qi, Lu

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Objective: We tested whether genetic variants near fatty acid desaturases gene (FADS) cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI). Design: Three FADS variants were examined for gene-diet interactions on long-term (∼10 years) changes in BMI and body weight in four prospective cohort studies. Setting: Population based study. Participants: 11 323 women from the Nurses' Health Study (NHS), 6833 men from the Health Professionals Follow-up Study (HPFS) and replicated in 6254 women from the Women's Health Initiative (WHI) and 5 264 Chinese from the Singapore Chinese Health Study (SCHS). Main outcomes: Long-term (∼10 years) changes in BMI and body weight. Results: In the NHS and HPFS cohorts, food-sourced n-3 PUFAs intake showed interactions with the FADS rs174570 on changes of BMI (P for interaction=0.02 in NHS, 0.05 in HPFS and 0.007 in combined). Such interactions were replicated in two independent cohorts WHI and SCHS (P for interaction=0.04 in WHI, 0.02 in SCHS and 0.001 in combined). The genetic associations of the FADS rs174570 with changes in BMI increased across the tertiles of n-3 PUFAs in all the cohorts. Fish intake also accentuated the genetic associations of the FADS rs174570 with long-term changes in BMI (pooled P for interaction=0.006). Viewed differently, long chain n-3 PUFAs intake showed stronger association with long-term changes in BMI among the rs174570 T carriers (beta=0.79 kg/m2 per g, p=3×10-5) than the rs174570 non-T carriers (beta=0.16 kg/m2 per g, p=0.08). Similar results were observed for fish intake. Conclusions: Our hypothesis-driven analyses provide replicable evidence that long chain n-3 PUFAs and fish intakes may interact with the FADS variant on long-term weight gain. Further investigation is needed to confirm our findings in other cohorts.

AB - Objective: We tested whether genetic variants near fatty acid desaturases gene (FADS) cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI). Design: Three FADS variants were examined for gene-diet interactions on long-term (∼10 years) changes in BMI and body weight in four prospective cohort studies. Setting: Population based study. Participants: 11 323 women from the Nurses' Health Study (NHS), 6833 men from the Health Professionals Follow-up Study (HPFS) and replicated in 6254 women from the Women's Health Initiative (WHI) and 5 264 Chinese from the Singapore Chinese Health Study (SCHS). Main outcomes: Long-term (∼10 years) changes in BMI and body weight. Results: In the NHS and HPFS cohorts, food-sourced n-3 PUFAs intake showed interactions with the FADS rs174570 on changes of BMI (P for interaction=0.02 in NHS, 0.05 in HPFS and 0.007 in combined). Such interactions were replicated in two independent cohorts WHI and SCHS (P for interaction=0.04 in WHI, 0.02 in SCHS and 0.001 in combined). The genetic associations of the FADS rs174570 with changes in BMI increased across the tertiles of n-3 PUFAs in all the cohorts. Fish intake also accentuated the genetic associations of the FADS rs174570 with long-term changes in BMI (pooled P for interaction=0.006). Viewed differently, long chain n-3 PUFAs intake showed stronger association with long-term changes in BMI among the rs174570 T carriers (beta=0.79 kg/m2 per g, p=3×10-5) than the rs174570 non-T carriers (beta=0.16 kg/m2 per g, p=0.08). Similar results were observed for fish intake. Conclusions: Our hypothesis-driven analyses provide replicable evidence that long chain n-3 PUFAs and fish intakes may interact with the FADS variant on long-term weight gain. Further investigation is needed to confirm our findings in other cohorts.

KW - epidemiology

KW - gene-diet interaction

KW - genetics

KW - obesity

UR - https://www.scopus.com/pages/publications/85070369417

U2 - 10.1136/bmjopen-2018-022877

DO - 10.1136/bmjopen-2018-022877

M3 - Article

C2 - 31371282

AN - SCOPUS:85070369417

SN - 2044-6055

VL - 9

JO - BMJ Open

JF - BMJ Open

IS - 7

M1 - e022877

ER -

Fish and marine fatty acids intakes, the FADS genotypes and long-term weight gain: A prospective cohort study

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Keywords

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