First report of blaIMP-14 on a plasmid harboring multiple drug resistance genes in Escherichia coli sequence type 131

Nicole Stoesser; Anna E. Sheppard; Gisele Peirano; Robert P. Sebra; Tarah Lynch; Luke W. Anson; Andrew Kasarskis; Mary R. Motyl; Derrick W. Crook; Johann D. Pitout

doi:10.1128/AAC.00840-16

First report of bla_IMP-14 on a plasmid harboring multiple drug resistance genes in Escherichia coli sequence type 131

Nicole Stoesser, Anna E. Sheppard, Gisele Peirano, Robert P. Sebra, Tarah Lynch, Luke W. Anson, Andrew Kasarskis, Mary R. Motyl, Derrick W. Crook, Johann D. Pitout

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15 Scopus citations

Abstract

The bla_IMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring bla_IMP-14 within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C₂ plasmid. The emergence of bla_IMP-14 in this context in the ST131 lineage is of potential clinical concern.

Original language	English
Pages (from-to)	5068-5071
Number of pages	4
Journal	Antimicrobial Agents and Chemotherapy
Volume	60
Issue number	8
DOIs	https://doi.org/10.1128/AAC.00840-16
State	Published - Aug 2016

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title = "First report of blaIMP-14 on a plasmid harboring multiple drug resistance genes in Escherichia coli sequence type 131",

abstract = "The blaIMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring blaIMP-14 within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C2 plasmid. The emergence of blaIMP-14 in this context in the ST131 lineage is of potential clinical concern.",

author = "Nicole Stoesser and Sheppard, {Anna E.} and Gisele Peirano and Sebra, {Robert P.} and Tarah Lynch and Anson, {Luke W.} and Andrew Kasarskis and Motyl, {Mary R.} and Crook, {Derrick W.} and Pitout, {Johann D.}",

note = "Publisher Copyright: Copyright {\textcopyright} 2016 Stoesser et al.",

year = "2016",

month = aug,

doi = "10.1128/AAC.00840-16",

language = "English",

volume = "60",

pages = "5068--5071",

journal = "Antimicrobial Agents and Chemotherapy",

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publisher = "American Society for Microbiology",

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T1 - First report of blaIMP-14 on a plasmid harboring multiple drug resistance genes in Escherichia coli sequence type 131

AU - Stoesser, Nicole

AU - Sheppard, Anna E.

AU - Peirano, Gisele

AU - Sebra, Robert P.

AU - Lynch, Tarah

AU - Anson, Luke W.

AU - Kasarskis, Andrew

AU - Motyl, Mary R.

AU - Crook, Derrick W.

AU - Pitout, Johann D.

PY - 2016/8

Y1 - 2016/8

N2 - The blaIMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring blaIMP-14 within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C2 plasmid. The emergence of blaIMP-14 in this context in the ST131 lineage is of potential clinical concern.

AB - The blaIMP-14 carbapenem resistance gene has largely previously been observed in Pseudomonas aeruginosa and Acinetobacter spp. As part of global surveillance and sequencing of carbapenem-resistant Escherichia coli, we identified a sequence type 131 strain harboring blaIMP-14 within a class 1 integron, itself nested within an ∼54-kb multidrug resistance region on an epidemic IncA/C2 plasmid. The emergence of blaIMP-14 in this context in the ST131 lineage is of potential clinical concern.

UR - http://www.scopus.com/inward/record.url?scp=84979271873&partnerID=8YFLogxK

U2 - 10.1128/AAC.00840-16

DO - 10.1128/AAC.00840-16

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AN - SCOPUS:84979271873

SN - 0066-4804

VL - 60

SP - 5068

EP - 5071

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 8

ER -

First report of blaIMP-14 on a plasmid harboring multiple drug resistance genes in Escherichia coli sequence type 131

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First report of bla_IMP-14 on a plasmid harboring multiple drug resistance genes in Escherichia coli sequence type 131