Finite strain analysis for biaxial isotropic flexible cell culture membranes

N. J. Tacy; D. Vashishth

Finite strain analysis for biaxial isotropic flexible cell culture membranes

N. J. Tacy
, D. Vashishth

Research output: Contribution to journal › Conference article › peer-review

Abstract

Anchorage dependant cells can be deformed on silicone membranes. These cells can respond to strain stimulus, and have been shown to differentiate, proliferate, and express different phenotypes [5]. The purpose of this study was to characterize the membrane substrate on which cells attach to. Lagrangian strain analysis was conducted with fluorescence emitting microspheres, having a diameter of 0.02μm. Stretch ratios were calculated for a deformed membrane surface at different positions and at different strains. The goal was to establish that uniform biaxial, isotropic strain exists for membranes deformed in a StageFlexer® chamber. Data indicates that uniform biaxial strain does occur. However, exact finite deformation characterization on the silicone membrane proves illusive as to the high degree of data variability.

Original language	English
Pages (from-to)	398-399
Number of pages	2
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	1
State	Published - 2002
Externally published	Yes
Event	Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States Duration: 23 Oct 2002 → 26 Oct 2002

Keywords

Finite strain
Fluorescent microspheres

Cite this

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title = "Finite strain analysis for biaxial isotropic flexible cell culture membranes",

abstract = "Anchorage dependant cells can be deformed on silicone membranes. These cells can respond to strain stimulus, and have been shown to differentiate, proliferate, and express different phenotypes [5]. The purpose of this study was to characterize the membrane substrate on which cells attach to. Lagrangian strain analysis was conducted with fluorescence emitting microspheres, having a diameter of 0.02μm. Stretch ratios were calculated for a deformed membrane surface at different positions and at different strains. The goal was to establish that uniform biaxial, isotropic strain exists for membranes deformed in a StageFlexer{\textregistered} chamber. Data indicates that uniform biaxial strain does occur. However, exact finite deformation characterization on the silicone membrane proves illusive as to the high degree of data variability.",

keywords = "Finite strain, Fluorescent microspheres",

author = "Tacy, \{N. J.\} and D. Vashishth",

year = "2002",

language = "English",

volume = "1",

pages = "398--399",

journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

issn = "0589-1019",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

note = "Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) ; Conference date: 23-10-2002 Through 26-10-2002",

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TY - JOUR

T1 - Finite strain analysis for biaxial isotropic flexible cell culture membranes

AU - Tacy, N. J.

AU - Vashishth, D.

PY - 2002

Y1 - 2002

N2 - Anchorage dependant cells can be deformed on silicone membranes. These cells can respond to strain stimulus, and have been shown to differentiate, proliferate, and express different phenotypes [5]. The purpose of this study was to characterize the membrane substrate on which cells attach to. Lagrangian strain analysis was conducted with fluorescence emitting microspheres, having a diameter of 0.02μm. Stretch ratios were calculated for a deformed membrane surface at different positions and at different strains. The goal was to establish that uniform biaxial, isotropic strain exists for membranes deformed in a StageFlexer® chamber. Data indicates that uniform biaxial strain does occur. However, exact finite deformation characterization on the silicone membrane proves illusive as to the high degree of data variability.

AB - Anchorage dependant cells can be deformed on silicone membranes. These cells can respond to strain stimulus, and have been shown to differentiate, proliferate, and express different phenotypes [5]. The purpose of this study was to characterize the membrane substrate on which cells attach to. Lagrangian strain analysis was conducted with fluorescence emitting microspheres, having a diameter of 0.02μm. Stretch ratios were calculated for a deformed membrane surface at different positions and at different strains. The goal was to establish that uniform biaxial, isotropic strain exists for membranes deformed in a StageFlexer® chamber. Data indicates that uniform biaxial strain does occur. However, exact finite deformation characterization on the silicone membrane proves illusive as to the high degree of data variability.

KW - Finite strain

KW - Fluorescent microspheres

UR - https://www.scopus.com/pages/publications/0036917297

M3 - Conference article

AN - SCOPUS:0036917297

SN - 0589-1019

VL - 1

SP - 398

EP - 399

JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

T2 - Proceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS)

Y2 - 23 October 2002 through 26 October 2002

ER -

Finite strain analysis for biaxial isotropic flexible cell culture membranes

Abstract

Keywords

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