Fine mapping of a deafness mutation hml on mouse chromosome 10

Qingyin Zheng, Belinda S. Harris, Patricia F. Ward-Bailey, Heping Yu, Roderick T. Bronson, Muriel T. Davisson, Kenneth R. Johnson

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Objective: To map a mouse deafness gene, identify the underlying mutation and develop a mouse model for human deafness. Methods: Genetic linkage cross and genome scan were used to map a novel mutation named hypoplasia of the membranous labyrinth (hml), which causes hearing loss in mutant mice. Results: Circled digit one hml was mapped on mouse Chr 10 (∼43 cM from the centromere), suggesting that the homologous human gene is on 12q22-q24, which was defined on the basis of known mouse-human homologies (OMIM, 2004). Circled digit two This study has generated 25 polymorphic microsatellite markers, placed 3 known human genes in the correct order in a high-resolution mouse map and narrowed the hml candidate gene region to a 500 kb area.

Original languageEnglish
Pages (from-to)209-212+260
JournalJournal of Xi'an Jiaotong University (Medical Sciences)
Volume25
Issue number3
StatePublished - Jun 2004
Externally publishedYes

Keywords

  • Deafness
  • Mouse
  • Mutation

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