TY - JOUR
T1 - FGF modulates the PDGF-driven pathway of oligodendrocyte development
AU - McKinnon, Randall D.
AU - Matsui, Toshimitsu
AU - Dubois-Dalcq, Monique
AU - Aaronsont, Stuart A.
N1 - Funding Information:
We thank Lynn Hudson, Regina Armstrong, and Bryn Watkins for comments on the manuscript, Bryn Watkins for advice on BUdR immunofluorescence, and Ray Rusten for photography. R. D. M. is supported by a senior fellowship from the U. S. National Multiple Sclerosis Society.
PY - 1990/11
Y1 - 1990/11
N2 - PDGF promotes the growth of oligodendrocyte type-2 astrocyte (O-2A) glial progenitor cells and allows their timely differentiation into oligodendrocytes, the CNS myelin-forming cells. We demonstrate that basic FGF is a potent mitogen for brain O-2A progenitor cells, but blocks their differentiation into oligodendrocytes. Treatment with basic FGF also influences the level of expression of PDGF receptors on O-2A progenitor cells. These cells express only the a chain PDGF receptor, and the levels of PDGF a receptors decrease as the cells differentiate. In contrast, basic FGF maintains a high level of functionally responsive PDGF a receptors in O-2A progenitors. Thus basic FGF activates a signaling pathway that can positively regulate PDGF receptors in O-2A progenitor cells. In this way basic FGF or an FGF-like factor may modulate the production of myelin-forming cells in the CNS.
AB - PDGF promotes the growth of oligodendrocyte type-2 astrocyte (O-2A) glial progenitor cells and allows their timely differentiation into oligodendrocytes, the CNS myelin-forming cells. We demonstrate that basic FGF is a potent mitogen for brain O-2A progenitor cells, but blocks their differentiation into oligodendrocytes. Treatment with basic FGF also influences the level of expression of PDGF receptors on O-2A progenitor cells. These cells express only the a chain PDGF receptor, and the levels of PDGF a receptors decrease as the cells differentiate. In contrast, basic FGF maintains a high level of functionally responsive PDGF a receptors in O-2A progenitors. Thus basic FGF activates a signaling pathway that can positively regulate PDGF receptors in O-2A progenitor cells. In this way basic FGF or an FGF-like factor may modulate the production of myelin-forming cells in the CNS.
UR - https://www.scopus.com/pages/publications/0025200507
U2 - 10.1016/0896-6273(90)90215-2
DO - 10.1016/0896-6273(90)90215-2
M3 - Article
C2 - 2171589
AN - SCOPUS:0025200507
SN - 0896-6273
VL - 5
SP - 603
EP - 614
JO - Neuron
JF - Neuron
IS - 5
ER -