Fetal hemoglobin in polycythemia vera: Cellular distribution in 50 unselected patients

R. Hoffman, T. Papayannopoulou, S. Landaw, L. R. Wasserman, Q. B. DeMarsh, P. Chen, G. Stamatoyannopoulos

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Fetal hemoglobin was studied in 50 unselected patients with polycythemia vera with chemical determinations of Hb F and measurements of F-cell levels using fluorescent anti-Hb F antibodies. Although in the majority of the patients Hb F production did not differ from that in normal controls, in 20% of the patients F-cell values were above the normal range. There was no correlation between F-cell values and duration of disease, treatment modality, presence of myelofibrosis, or hematologic parameters at the time of study. In 5 of 50 patients 30%-45% of the erythrocytes contained Hb F; such striking elevations of F cells may reflect a distorted differentiation of erythroid precursor cells in certain patients with this disorder.

Original languageEnglish
Pages (from-to)1148-1155
Number of pages8
JournalBlood
Volume53
Issue number6
DOIs
StatePublished - 1979

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