Fetal fibronectin and preterm labor

Ronald F. Feinberg, Harvey J. Kliman, Yoel Sadovsky, Steven A. Friedman, Charles J. Lockwood, Andrew E. Senyei, M. Renate Dische, David Casal, Kumudini D. Shah, Swan N. Thung, Lynn Jones, Liane Deligdisch, Thomas J. Garite

Research output: Contribution to journalLetterpeer-review

14 Scopus citations


To the Editor: We applaud Lockwood et al. (Sept. 5 issue)1 for their multicenter study aimed at identifying a biochemical marker for preterm labor and delivery. However, it seems that the authors may have done themselves and the readers a disservice by not appreciating the implications of our previous collaborative efforts on this topic. For example, the cellular sources of “fetal” fibronectin had previously been unclear, but our studies revealed that the fibronectin was probably not fetal in origin. Specifically, using monoclonal antibody FDC-6 as an immunohistochemical probe, we found that oncofetal fibronectin is deposited by anchoring trophoblasts and chorionic.

Original languageEnglish
Pages (from-to)708-709
Number of pages2
JournalNew England Journal of Medicine
Issue number10
StatePublished - 5 Mar 1992


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