Fetal fibronectin and preterm labor

Ronald F. Feinberg; Harvey J. Kliman; Yoel Sadovsky; Steven A. Friedman; Charles J. Lockwood; Andrew E. Senyei; M. Renate Dische; David Casal; Kumudini D. Shah; Swan N. Thung; Lynn Jones; Liane Deligdisch; Thomas J. Garite

doi:10.1056/NEJM199203053261013

Fetal fibronectin and preterm labor

Ronald F. Feinberg, Harvey J. Kliman, Yoel Sadovsky, Steven A. Friedman, Charles J. Lockwood, Andrew E. Senyei, M. Renate Dische, David Casal, Kumudini D. Shah, Swan N. Thung, Lynn Jones, Liane Deligdisch, Thomas J. Garite

Research output: Contribution to journal › Letter › peer-review

14 Scopus citations

Abstract

To the Editor: We applaud Lockwood et al. (Sept. 5 issue)¹ for their multicenter study aimed at identifying a biochemical marker for preterm labor and delivery. However, it seems that the authors may have done themselves and the readers a disservice by not appreciating the implications of our previous collaborative efforts on this topic. For example, the cellular sources of “fetal” fibronectin had previously been unclear, but our studies revealed that the fibronectin was probably not fetal in origin. Specifically, using monoclonal antibody FDC-6 as an immunohistochemical probe, we found that oncofetal fibronectin is deposited by anchoring trophoblasts and chorionic.

Original language	English
Pages (from-to)	708-709
Number of pages	2
Journal	New England Journal of Medicine
Volume	326
Issue number	10
DOIs	https://doi.org/10.1056/NEJM199203053261013
State	Published - 5 Mar 1992

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title = "Fetal fibronectin and preterm labor",

abstract = "To the Editor: We applaud Lockwood et al. (Sept. 5 issue)1 for their multicenter study aimed at identifying a biochemical marker for preterm labor and delivery. However, it seems that the authors may have done themselves and the readers a disservice by not appreciating the implications of our previous collaborative efforts on this topic. For example, the cellular sources of “fetal” fibronectin had previously been unclear, but our studies revealed that the fibronectin was probably not fetal in origin. Specifically, using monoclonal antibody FDC-6 as an immunohistochemical probe, we found that oncofetal fibronectin is deposited by anchoring trophoblasts and chorionic.",

author = "Feinberg, {Ronald F.} and Kliman, {Harvey J.} and Yoel Sadovsky and Friedman, {Steven A.} and Lockwood, {Charles J.} and Senyei, {Andrew E.} and Dische, {M. Renate} and David Casal and Shah, {Kumudini D.} and Thung, {Swan N.} and Lynn Jones and Liane Deligdisch and Garite, {Thomas J.}",

year = "1992",

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doi = "10.1056/NEJM199203053261013",

language = "English",

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TY - JOUR

T1 - Fetal fibronectin and preterm labor

AU - Feinberg, Ronald F.

AU - Kliman, Harvey J.

AU - Sadovsky, Yoel

AU - Friedman, Steven A.

AU - Lockwood, Charles J.

AU - Senyei, Andrew E.

AU - Dische, M. Renate

AU - Casal, David

AU - Shah, Kumudini D.

AU - Thung, Swan N.

AU - Jones, Lynn

AU - Deligdisch, Liane

AU - Garite, Thomas J.

PY - 1992/3/5

Y1 - 1992/3/5

N2 - To the Editor: We applaud Lockwood et al. (Sept. 5 issue)1 for their multicenter study aimed at identifying a biochemical marker for preterm labor and delivery. However, it seems that the authors may have done themselves and the readers a disservice by not appreciating the implications of our previous collaborative efforts on this topic. For example, the cellular sources of “fetal” fibronectin had previously been unclear, but our studies revealed that the fibronectin was probably not fetal in origin. Specifically, using monoclonal antibody FDC-6 as an immunohistochemical probe, we found that oncofetal fibronectin is deposited by anchoring trophoblasts and chorionic.

AB - To the Editor: We applaud Lockwood et al. (Sept. 5 issue)1 for their multicenter study aimed at identifying a biochemical marker for preterm labor and delivery. However, it seems that the authors may have done themselves and the readers a disservice by not appreciating the implications of our previous collaborative efforts on this topic. For example, the cellular sources of “fetal” fibronectin had previously been unclear, but our studies revealed that the fibronectin was probably not fetal in origin. Specifically, using monoclonal antibody FDC-6 as an immunohistochemical probe, we found that oncofetal fibronectin is deposited by anchoring trophoblasts and chorionic.

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U2 - 10.1056/NEJM199203053261013

DO - 10.1056/NEJM199203053261013

M3 - Letter

C2 - 1736115

AN - SCOPUS:0026592669

SN - 0028-4793

VL - 326

SP - 708

EP - 709

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 10

ER -

Fetal fibronectin and preterm labor

Abstract

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