Fetal cardiac activity at 4 weeks after in vitro fertilization predicts successful completion of the first trimester of pregnancy

Aimee Seungdamrong, Mamta Purohit, David H. McCulloh, Richard D. Howland, Jose M. Colon, Peter G. McGovern

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Objective: To determine the predictive value of fetal cardiac activity (FCA), measured at 6 weeks' gestation, on first-trimester pregnancy success after IVF. Design: Retrospective cohort study. Setting: University-based reproductive endocrinology and infertility practice. Patient(s): One hundred thirty-nine women, without a history of recurrent miscarriage, who were undergoing fresh IVF cycles from August 1, 2004 to February 28, 2005. Intervention(s): Transvaginal ultrasound. Main Outcome Measure(s): First-trimester pregnancy success. Result(s): Ninety-three percent (51/53) of gestational sacs with FCA completed the first trimester (positive predictive value of 93%). Eighty-seven percent (13/15) of sacs without FCA failed in the first trimester (negative predictive value of 87%). In singletons, the positive and negative predictive value of FCA on first-trimester success was 100%. All twin pregnancies (n = 11) successfully completed the first trimester. Conclusion(s): This analysis, which was performed strictly in an IVF population with no history of recurrent pregnancy loss, demonstrates that positive FCA at 6 weeks' gestation is an excellent predictor of first-trimester pregnancy outcome.

Original languageEnglish
Pages (from-to)1711-1715
Number of pages5
JournalFertility and Sterility
Volume90
Issue number5
DOIs
StatePublished - Nov 2008
Externally publishedYes

Keywords

  • Fetal cardiac activity
  • abortion rate
  • fetal heart rate
  • in vitro fertilization
  • infertility
  • pregnancy rate

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