Fertility in patients with nonclassical congenital adrenal hyperplasia

Maria I. New, Lucia Ghizzoni, Heino Meyer-Bahlburg, Ahmed Khattab, David Reichman, Zev Rosenwaks

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations

Abstract

Nonclassical congenital adrenal hyperplasia (NC-CAH) is by far a subtler and milder enzymatic defect to the classical form of the disease. A nuanced understanding of NC-CAH will lead to increased detection of the disorder in those initially misdiagnosed as having polycystic ovary syndrome, will assist in the detection of pregnancies at risk for severe genetic steroid disorders, and will facilitate appropriate ovulation induction and reduction in the hyperandrogenic symptoms which are a cornerstone of the disease. We describe the history of the disease as well as elucidate the pathophysiology, diagnosis, and treatment of the disorder.

Original languageEnglish
Pages (from-to)13-20
Number of pages8
JournalFertility and Sterility
Volume111
Issue number1
DOIs
StatePublished - Jan 2019

Keywords

  • 17-OHP
  • 21-hydroxylase
  • Adrenal steroid disorder
  • NC-CAH
  • congenital adrenal hyperplasia

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