Feminizing adrenocortical carcinoma in a man

A second instance of a feminizing adrenocortical tumor studied in this laboratory is reported. A marked increase in the production rates of estrone and estradiol was demonstrated as well as in the urinary excretion of estogens. These latter were partitioned into 16‐hydroxyestrone, 16‐ketoestradiol, and 16‐epiestriol as well as the classical estrogens. The secretory rate of cortisol was low whereas that of 11‐deoxycortisol was markedly increased. The urinary excretion of testosterone was normal in spite of marked feminization and atrophy of the testes. Of interest was the demonstration of the marked conversion into estrogen of androstenedione and testosterone administered intravenously. In addition, 8 further instances of feminizing adrenocortical carcinoma collected from the literature are reviewed.